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<v Speaker 1>This session of the 2013 Adelaide Festival of Ideas was recorded by Radio Adelaide,

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<v Speaker 1>through the support of the Bar Smith Library, University of Adelaide,

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<v Speaker 1>the University of South Australia Library and Flinders University Library.

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<v Robyn Williams>I thought I'd celebrate by having the most important person Australia could boast in science.

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<v Robyn Williams>Trouble is they'd been on recently already, Sir Macfarlane Burnett, a couple of other people,

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<v Robyn Williams>so I decided to invent one whom I called Sir Clarence Lovejoy,

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<v Robyn Williams>who got his Nobel Prizes for brain flux theory,

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<v Robyn Williams>where you could talk about manipulating the brain by putting various needles in,

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<v Robyn Williams>into the lobus levitatus, and the rat started to laugh.

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<v Robyn Williams>Or in the pons ponderosus, if you put the pin into the brain,

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<v Robyn Williams>it crossed its paws and started to ponder.

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<v Robyn Williams>And the main...

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<v Robyn Williams>You always have to have an application, and so I said that Sir Clarence invented

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<v Robyn Williams>a cerebral flange wick, which you could implant,

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<v Robyn Williams>and especially in politicians, it overcame deficiencies in megalomania.

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<v Robyn Williams>And we broadcast this, and people believed it.

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<v Robyn Williams>And we went on any number of television current affairs programs,

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<v Robyn Williams>and he was treated quite seriously.

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<v Robyn Williams>He was in fact an actor who was a professor of philosophy at the University of Sydney,

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<v Robyn Williams>Fred May, who's now deceased.

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<v Robyn Williams>And it was just incredible how you could invent a malady,

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<v Robyn Williams>and people would take it seriously.

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<v Robyn Williams>Now this is what, to some extent, Gary is talking about in his book,

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<v Robyn Williams>that you can actually place people as if they are in a box,

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<v Robyn Williams>which you can identify as a malady defined by science,

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<v Robyn Williams>when in fact there is a flux and a fashion that's quite...

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<v Robyn Williams>Now, I was reminded when I heard you on radio last night

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<v Robyn Williams>of Thomas and his book, The Melody of Science,

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<v Robyn Williams>and I was reminded of Thomas Satz,

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<v Robyn Williams>who was saying similar sorts of things a generation ago,

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<v Robyn Williams>and he wasn't really an anti-psychiatrist.

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<v Robyn Williams>He was someone who was suggesting

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<v Robyn Williams>that psychiatry was too ready-giving definitions,

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<v Robyn Williams>and there was not enough science behind it.

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<v Robyn Williams>That was the point.

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<v Robyn Williams>There was fashion behind it, but not enough science.

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<v Robyn Williams>And I asked him the question,

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<v Robyn Williams>how do you give therapy, because Gary gives therapy,

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<v Robyn Williams>how do you provide therapy for patients

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<v Robyn Williams>if you are, at the same time, in public,

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<v Robyn Williams>giving doubt about the entire field?

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<v Robyn Williams>So it's an intriguing situation.

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<v Robyn Williams>The Book of Woe, I don't know whether you...

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<v Robyn Williams>That is a title which instantly becomes a bestseller.

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<v Robyn Williams>But would you stand up and talk to us for 35 minutes?

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<v Robyn Williams>And then after that we'll have some Q&A. Thank you.

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<v Gary Greenberg>Thank you, Robin, for that introduction,

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<v Gary Greenberg>and for the watch.

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<v Gary Greenberg>See, I've had all these troubles since I've been in your country.

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<v Gary Greenberg>I've contributed greatly to your GDP.

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<v Gary Greenberg>I have purchased a computer and a phone since I've been here.

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<v Gary Greenberg>And anybody that wants to come up

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<v Gary Greenberg>and show me how to get my phone to work right afterwards,

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<v Gary Greenberg>I'm all for that.

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<v Gary Greenberg>So I'm relying on Robin's watch to keep time,

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<v Gary Greenberg>which is analog, I would note.

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<v Gary Greenberg>So the answer to the question

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<v Gary Greenberg>of how Tom Sotz would practice therapy

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<v Gary Greenberg>is we have to remember psychoanalysis,

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<v Gary Greenberg>which is sort of the background of psychotherapy in the Western world,

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<v Gary Greenberg>was founded by Freud.

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<v Gary Greenberg>Freud was a self-hating Jew.

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<v Gary Greenberg>So what that means is that it's a practice

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<v Gary Greenberg>that's always going to be, in some respects,

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<v Gary Greenberg>in conflict with itself.

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<v Gary Greenberg>Now that tendency to have a discipline

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<v Gary Greenberg>that's in conflict with itself

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<v Gary Greenberg>has, in recent years, begun to fall apart.

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<v Gary Greenberg>The DSM, the Diagnostic and Statistical Manual,

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<v Gary Greenberg>is an attempt to find certainty

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<v Gary Greenberg>in a field which is inherently uncertain.

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<v Gary Greenberg>That is the field of human behavior.

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<v Gary Greenberg>I'm, for one, pleased to say

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<v Gary Greenberg>that I think that until the end,

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<v Gary Greenberg>we will defy our own understanding.

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<v Gary Greenberg>I don't have any problem with that

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<v Gary Greenberg>except for when I wake up at 2 o'clock in the morning

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<v Gary Greenberg>with a sudden attack of dread.

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<v Gary Greenberg>I'm going to be very upset and wish I knew why.

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<v Gary Greenberg>But I want to start with that

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<v Gary Greenberg>because I want to let you know

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<v Gary Greenberg>that what I'm talking about is a highly contentious

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<v Gary Greenberg>and strongly contended field.

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<v Gary Greenberg>And since I've been in Australia,

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<v Gary Greenberg>I've been exposed to something that,

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<v Gary Greenberg>while I've heard in the States,

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<v Gary Greenberg>it hasn't been quite so common,

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<v Gary Greenberg>which is the radio and TV shows

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<v Gary Greenberg>and the people that I've talked to in bookstores,

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<v Gary Greenberg>they all seem to, at least one of them,

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<v Gary Greenberg>in every situation, wants to ask me a question.

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<v Gary Greenberg>They want to know,

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<v Gary Greenberg>are you a Scientologist?

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<v Gary Greenberg>Now, there's a reason for them to ask me that.

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<v Gary Greenberg>You know, Scientologists believe that psychiatry

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<v Gary Greenberg>is an evil cabal

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<v Gary Greenberg>which is dedicated to preventing people

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<v Gary Greenberg>from becoming Scientologists.

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<v Gary Greenberg>And therefore thinks that everything that psychiatry does is evil.

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<v Gary Greenberg>On the other hand, psychiatrists believe

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<v Gary Greenberg>that Scientology is an evil cabal

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<v Gary Greenberg>dedicated to preventing people from going to psychiatrists.

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<v Gary Greenberg>And consequently, most criticisms of psychiatry

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<v Gary Greenberg>fall into this category that Robin mentioned

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<v Gary Greenberg>called anti-psychiatry.

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<v Gary Greenberg>So I want to be really clear.

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<v Gary Greenberg>Let me just add that this is what psychiatrists do,

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<v Gary Greenberg>for better or for worse.

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<v Gary Greenberg>They take something that's troublesome

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<v Gary Greenberg>and they diagnose it.

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<v Gary Greenberg>In this case, they diagnose me as an anti-psychiatrist.

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<v Gary Greenberg>Well, actually, I'm neither a Scientologist nor a psychiatrist.

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<v Gary Greenberg>I have a PhD in psychology, and I'm a lapsed,

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<v Gary Greenberg>Jewish Jew, not a Scientologist.

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<v Gary Greenberg>And in fact, I don't believe very much in conspiracies at all.

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<v Gary Greenberg>I think that conspiracies probably exist,

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<v Gary Greenberg>but they tend to require more competence

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<v Gary Greenberg>than most people have.

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<v Gary Greenberg>And especially about important things like

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<v Gary Greenberg>naming the mental illnesses in the world,

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<v Gary Greenberg>or to put it another way,

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<v Gary Greenberg>trying to come to an understanding of our suffering.

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<v Gary Greenberg>But I also don't believe very much in coincidences.

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<v Gary Greenberg>And I think that when we have a phenomenon

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<v Gary Greenberg>that's as pervasive and troubling

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<v Gary Greenberg>in the jump in psychiatric diagnosis and treatment

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<v Gary Greenberg>that we've seen in the last 15 or let's call it 25 years,

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<v Gary Greenberg>I don't think we're in the presence of either conspiracy or coincidence.

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<v Gary Greenberg>Which actually, they're not very interesting ways to tell a story anyway.

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<v Gary Greenberg>I think what we are when we observe something like this

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<v Gary Greenberg>is we're deep in the grips of history.

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<v Gary Greenberg>Now, that doesn't mean that the DSM-5,

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<v Gary Greenberg>the Diagnostic and Statistical Manual that I wrote about,

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<v Gary Greenberg>isn't a problem, or that it is...

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<v Gary Greenberg>It's just that it's no worse

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<v Gary Greenberg>than any other diagnostic manual that's come along.

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<v Gary Greenberg>It doesn't mean that it's 1,000 pages

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<v Gary Greenberg>and 250 psychiatric diagnoses

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<v Gary Greenberg>naming the suffering that people experience

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<v Gary Greenberg>from everything from adjustment disorder,

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<v Gary Greenberg>you can figure out what that is,

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<v Gary Greenberg>to schizophrenia, aren't important.

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<v Gary Greenberg>It's just to say that that book,

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<v Gary Greenberg>is not the product of a conspiracy.

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<v Gary Greenberg>It is the product of a lot of people who are trying to do good work,

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<v Gary Greenberg>but are, just like everybody else,

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<v Gary Greenberg>bounded by history.

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<v Gary Greenberg>I think that there's an idea

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<v Gary Greenberg>behind psychiatric diagnosis,

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<v Gary Greenberg>and it's a fairly simple idea.

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<v Gary Greenberg>The idea is that when...

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<v Gary Greenberg>The idea is that craziness is illness.

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<v Gary Greenberg>I don't mean to deny that craziness exists,

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<v Gary Greenberg>or that it's important,

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<v Gary Greenberg>or that it causes suffering,

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<v Gary Greenberg>or that it's frightening.

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<v Gary Greenberg>And I don't even know if I mean to deny that it's sickness.

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<v Gary Greenberg>What I mean to say here today

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<v Gary Greenberg>is that we don't know yet

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<v Gary Greenberg>whether craziness is medical illness.

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<v Gary Greenberg>And the medical establishment,

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<v Gary Greenberg>particularly psychiatry,

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<v Gary Greenberg>has spent the last 15 or 20 years

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<v Gary Greenberg>acting as if, indeed, we do know that.

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<v Gary Greenberg>It's actually more than that,

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<v Gary Greenberg>but it's really come to a head in those years.

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<v Gary Greenberg>Now, I think this reflexive notion

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<v Gary Greenberg>that mental illness,

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<v Gary Greenberg>that craziness is mental illness,

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<v Gary Greenberg>I think, you know, you hear it all the time, right?

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<v Gary Greenberg>Something terrible happens.

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<v Gary Greenberg>Somebody does a mass murder.

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<v Gary Greenberg>I wrote a story once about Ted Kaczynski,

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<v Gary Greenberg>who was the Unabomber in the States,

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<v Gary Greenberg>and he was diagnosed with paranoid schizophrenia.

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<v Gary Greenberg>I spent two years in correspondence with Kaczynski.

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<v Gary Greenberg>He was an evil guy.

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<v Gary Greenberg>He had terrible ideas,

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<v Gary Greenberg>but he wasn't sick.

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<v Gary Greenberg>And yet our reflex is to think

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<v Gary Greenberg>that whenever anything happens like that,

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<v Gary Greenberg>the person is sick.

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<v Gary Greenberg>I think that reflex needs to be questioned.

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<v Gary Greenberg>And I'm a therapist,

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<v Gary Greenberg>and the premise of therapy is that

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<v Gary Greenberg>when you have a troublesome idea,

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<v Gary Greenberg>one that's shaping your view of the world

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<v Gary Greenberg>without you knowing why,

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<v Gary Greenberg>or even that you're knowing that it's doing it,

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<v Gary Greenberg>and when that idea is not quite working,

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<v Gary Greenberg>you have to go on archaeological expeditions

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<v Gary Greenberg>to figure out what's going on

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<v Gary Greenberg>and to try to treat it.

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<v Gary Greenberg>Now, my evidence that the idea isn't working

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<v Gary Greenberg>is simply this.

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<v Gary Greenberg>Psychiatry is in tremendous disarray

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<v Gary Greenberg>and it's not a good idea.

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<v Gary Greenberg>I'm sure that most of the people here

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<v Gary Greenberg>are at least skeptical about psychiatric diagnosis

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<v Gary Greenberg>and psychiatric treatment.

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<v Gary Greenberg>I'm sure that most of the people here

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<v Gary Greenberg>who happen to be on psychiatric drugs

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<v Gary Greenberg>wonder why they're on them sometimes,

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<v Gary Greenberg>wonder whether it's a good idea for them to be on them,

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<v Gary Greenberg>or wonder whether they should give their children psychiatric drugs.

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<v Gary Greenberg>And unfortunately,

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<v Gary Greenberg>we don't have very good answers to that question.

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<v Gary Greenberg>We're going along on empirical science,

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<v Gary Greenberg>I'm sorry, on empirical observation

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<v Gary Greenberg>and not on science.

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<v Gary Greenberg>Because I want to give you some thoughts today

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<v Gary Greenberg>about how we got to this strange point in history

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<v Gary Greenberg>where craziness is considered a disease.

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<v Gary Greenberg>You know, over the years,

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<v Gary Greenberg>craziness has been considered sin,

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<v Gary Greenberg>witchcraft, devil possession,

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<v Gary Greenberg>the sign of divine inspiration,

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<v Gary Greenberg>the sign of artistic inspiration,

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<v Gary Greenberg>but now we think of it as a disease,

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<v Gary Greenberg>which means, at least in capitalist societies,

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<v Gary Greenberg>to get to the title of the talk,

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<v Gary Greenberg>it means a market.

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<v Gary Greenberg>Because every disease is a market.

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<v Gary Greenberg>Not just for drug companies, and we'll get to that,

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<v Gary Greenberg>but for practitioners like me.

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<v Gary Greenberg>We treat diseases,

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<v Gary Greenberg>and when we do, we get paid to do it.

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<v Gary Greenberg>Now what I want to do is I want to give you a quick case history,

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<v Gary Greenberg>but I don't want the case history to be of a person,

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<v Gary Greenberg>I want the case history to be of a psychiatric disorder.

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<v Gary Greenberg>This is a psychiatric disorder that arose in the 1990s,

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<v Gary Greenberg>after those of you who were around then will remember

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<v Gary Greenberg>that there was a great deal of cultural displacement

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<v Gary Greenberg>in the 1980s and the 1990s,

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<v Gary Greenberg>with the rise of the internet,

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<v Gary Greenberg>it was the rise of many things,

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<v Gary Greenberg>and what my experience was, I'm 56,

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<v Gary Greenberg>so I was in my salad days in the 1980s,

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<v Gary Greenberg>what I remember is that life got a whole lot faster,

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<v Gary Greenberg>and there was a whole lot more distraction,

241
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<v Gary Greenberg>and it was a whole lot harder to concentrate,

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<v Gary Greenberg>to the point today where nobody can concentrate.

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<v Gary Greenberg>Where they have to tell you to shut off your cell phones at the movie theater,

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<v Gary Greenberg>because everybody will be on their cell phones while they're at the movie theater.

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<v Gary Greenberg>So we've come a long way, I'm not sure it's a good way,

246
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<v Gary Greenberg>but one of the things that happened at the same time

247
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<v Gary Greenberg>that the speed of life was ramping up,

248
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<v Gary Greenberg>and the number of distractions was multiplying exponentially,

249
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<v Gary Greenberg>was that there was a rash, an epidemic,

250
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<v Gary Greenberg>of a childhood psychiatric disorder,

251
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<v Gary Greenberg>you all know what I'm going to say,

252
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<v Gary Greenberg>attention deficit hyperactivity disorder,

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<v Gary Greenberg>better known as ADHD.

254
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<v Gary Greenberg>Now, I'm not trying to imply cause and effect,

255
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<v Gary Greenberg>but those are two really interesting parallel occurrences.

256
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<v Gary Greenberg>And one thing you need to know,

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<v Gary Greenberg>from right off the bat in psychiatry,

258
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<v Gary Greenberg>is that the focus has always been

259
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<v Gary Greenberg>on what's wrong with the kid who can't concentrate.

260
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<v Gary Greenberg>And in focusing there,

261
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<v Gary Greenberg>the focus has been on what's going on inside his brain

262
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<v Gary Greenberg>that makes him say he can't concentrate.

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<v Gary Greenberg>That's why when the Ritalin or the Adderall work,

264
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<v Gary Greenberg>the explanation is,

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<v Gary Greenberg>well, it solved some kind of a chemical problem that the kid had.

266
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<v Gary Greenberg>Now, anybody that's taken one of those stimulants knows,

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<v Gary Greenberg>that if you take a stimulant, you suddenly become,

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<v Gary Greenberg>I had a girl describe it to me the other day,

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<v Gary Greenberg>like a horse with blinkers on.

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<v Gary Greenberg>It's like your brain is a magnet

271
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<v Gary Greenberg>and the work you're trying to work on is metal.

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<v Gary Greenberg>That's why so many brain workers who don't have ADHD

273
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<v Gary Greenberg>like to use it.

274
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<v Gary Greenberg>It's like coffee, only it doesn't hurt your bladder.

275
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<v Gary Greenberg>Now, the kids that we all know,

276
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<v Gary Greenberg>I mean, this was infamous,

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<v Gary Greenberg>the rates of diagnosis and treatment were helped.

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<v Gary Greenberg>I'm not trying to advocate for it,

279
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<v Gary Greenberg>but we have to at least acknowledge

280
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<v Gary Greenberg>that some of these kids were helped,

281
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<v Gary Greenberg>as is almost always the case with psychiatric drugs.

282
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<v Gary Greenberg>The market decides.

283
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<v Gary Greenberg>If they don't work, they don't stay.

284
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<v Gary Greenberg>But there was a few kids,

285
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<v Gary Greenberg>and actually an increasing number,

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<v Gary Greenberg>who not only didn't respond well to stimulants,

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<v Gary Greenberg>but got worse.

288
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<v Gary Greenberg>And then when they weren't on any drugs at all,

289
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<v Gary Greenberg>they got even worse.

290
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<v Gary Greenberg>These were children who were explosive,

291
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<v Gary Greenberg>who threw temper tantrums up through the age of 10 or 12.

292
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<v Gary Greenberg>They were scary, violent,

293
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<v Gary Greenberg>children who parents couldn't manage

294
00:13:15.700 --> 00:13:17.100
<v Gary Greenberg>and teachers couldn't manage.

295
00:13:17.240 --> 00:13:19.740
<v Gary Greenberg>And they worked their way through the mental health system

296
00:13:20.380 --> 00:13:23.520
<v Gary Greenberg>until they finally got to the top tier.

297
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<v Gary Greenberg>In the United States, that would be Harvard University.

298
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<v Gary Greenberg>I got paid to say that.

299
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<v Gary Greenberg>Now, we might think of these kids,

300
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<v Gary Greenberg>I think of these kids,

301
00:13:35.280 --> 00:13:38.020
<v Gary Greenberg>as sort of like your antibiotic-resistant bacteria.

302
00:13:38.260 --> 00:13:40.060
<v Gary Greenberg>Not to call children bacteria or anything.

303
00:13:40.360 --> 00:13:41.640
<v Gary Greenberg>There aren't any here, are there?

304
00:13:42.600 --> 00:13:48.560
<v Gary Greenberg>Or your, you know, pesticide-resistant bugs.

305
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<v Gary Greenberg>They somehow defied the treatment,

306
00:13:51.780 --> 00:13:53.340
<v Gary Greenberg>and indeed got stronger.

307
00:13:53.800 --> 00:13:56.140
<v Gary Greenberg>What we were seeing was a kind of super ADHD.

308
00:13:57.780 --> 00:14:00.360
<v Gary Greenberg>And clinicians, unable to deal with it,

309
00:14:00.380 --> 00:14:01.520
<v Gary Greenberg>having sent them to Harvard,

310
00:14:02.360 --> 00:14:05.020
<v Gary Greenberg>the children were met by a team at Harvard,

311
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<v Gary Greenberg>some of them anyway,

312
00:14:06.500 --> 00:14:07.460
<v Gary Greenberg>were met by a team at Harvard

313
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<v Gary Greenberg>led by a psychiatrist named Joseph Biederman.

314
00:14:10.360 --> 00:14:12.580
<v Gary Greenberg>Now, Joseph Biederman was a prominent American,

315
00:14:12.600 --> 00:14:15.400
<v Gary Greenberg>psychiatrist, he's what's called a key opinion leader,

316
00:14:15.560 --> 00:14:17.660
<v Gary Greenberg>a KOL in the parlance.

317
00:14:18.060 --> 00:14:20.980
<v Gary Greenberg>And Biederman decided that these children

318
00:14:20.980 --> 00:14:23.000
<v Gary Greenberg>weren't suffering from ADHD at all.

319
00:14:23.180 --> 00:14:25.720
<v Gary Greenberg>What they were suffering from, he said,

320
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<v Gary Greenberg>was bipolar disorder.

321
00:14:28.800 --> 00:14:31.880
<v Gary Greenberg>Now, no one knows exactly why Biederman came up with this.

322
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<v Gary Greenberg>He came, there were some studies that he did

323
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<v Gary Greenberg>that if you read them, if you can,

324
00:14:35.840 --> 00:14:37.360
<v Gary Greenberg>I'm not gonna bother you with them,

325
00:14:37.420 --> 00:14:39.260
<v Gary Greenberg>but if you penetrate through them,

326
00:14:39.320 --> 00:14:41.340
<v Gary Greenberg>they sort of make it look like,

327
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<v Gary Greenberg>it could be the case.

328
00:14:43.620 --> 00:14:46.560
<v Gary Greenberg>But there was no reason to choose bipolar disorder.

329
00:14:46.820 --> 00:14:48.900
<v Gary Greenberg>And for two reasons I say that.

330
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<v Gary Greenberg>One of them is that bipolar disorder

331
00:14:51.040 --> 00:14:53.120
<v Gary Greenberg>requires episodic mania.

332
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<v Gary Greenberg>Bipolar disorder used to be called manic depression.

333
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<v Gary Greenberg>From psychotic excitement

334
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<v Gary Greenberg>to suicidal depression, back and forth.

335
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<v Gary Greenberg>Episodic mania is unheard of in children.

336
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<v Gary Greenberg>Unless you consider childhood to be

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<v Gary Greenberg>one long manic episode.

338
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<v Gary Greenberg>So there was no reason to choose

339
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<v Gary Greenberg>bipolar disorder.

340
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<v Gary Greenberg>There was no reason to diagnose,

341
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<v Gary Greenberg>they were immediately excluded from the diagnosis.

342
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<v Gary Greenberg>And interestingly, and this is the second reason

343
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<v Gary Greenberg>I say there was no reason,

344
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<v Gary Greenberg>there was a diagnosis in the Diagnostic and Statistical Manual

345
00:15:21.800 --> 00:15:23.340
<v Gary Greenberg>that suited these children just fine.

346
00:15:23.520 --> 00:15:25.940
<v Gary Greenberg>It was called oppositional defiant disorder.

347
00:15:26.940 --> 00:15:29.420
<v Gary Greenberg>And, well, you can tell from the title, right?

348
00:15:29.580 --> 00:15:31.520
<v Gary Greenberg>It's a great example of a description

349
00:15:31.520 --> 00:15:32.820
<v Gary Greenberg>that's not really an explanation,

350
00:15:33.060 --> 00:15:34.240
<v Gary Greenberg>but you take it up one notch,

351
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<v Gary Greenberg>you say, well, that kid's oppositional,

352
00:15:36.740 --> 00:15:39.380
<v Gary Greenberg>or you say, no, no, he's oppositional defiant disorder.

353
00:15:39.380 --> 00:15:42.660
<v Gary Greenberg>And suddenly you've made it science, right?

354
00:15:43.040 --> 00:15:45.640
<v Gary Greenberg>And the problem with ODD,

355
00:15:45.720 --> 00:15:47.380
<v Gary Greenberg>as we call it in the trade,

356
00:15:47.720 --> 00:15:49.040
<v Gary Greenberg>I'll let you in on that secret,

357
00:15:49.100 --> 00:15:50.680
<v Gary Greenberg>and the secret handshake will be for sale

358
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<v Gary Greenberg>at the end of this lecture.

359
00:15:53.560 --> 00:15:55.440
<v Gary Greenberg>The reason that they didn't want

360
00:15:55.440 --> 00:15:57.740
<v Gary Greenberg>to give these kids the diagnosis of ODD

361
00:15:57.740 --> 00:16:00.060
<v Gary Greenberg>was as somebody who was close to these proceedings

362
00:16:00.060 --> 00:16:03.420
<v Gary Greenberg>explained it, it has a bad reputation.

363
00:16:04.780 --> 00:16:06.580
<v Gary Greenberg>The reason it has a bad reputation

364
00:16:06.580 --> 00:16:08.260
<v Gary Greenberg>is exactly the reason that you,

365
00:16:08.260 --> 00:16:09.560
<v Gary Greenberg>those of you who laughed

366
00:16:09.560 --> 00:16:11.760
<v Gary Greenberg>when I said oppositional defiant disorder, laughed.

367
00:16:12.260 --> 00:16:13.600
<v Gary Greenberg>Because it sounds ridiculous,

368
00:16:13.720 --> 00:16:14.520
<v Gary Greenberg>and it sounds trivial,

369
00:16:14.700 --> 00:16:17.000
<v Gary Greenberg>and it sounds like pathologizing normalcy,

370
00:16:17.060 --> 00:16:18.380
<v Gary Greenberg>and it sounds like, well,

371
00:16:18.460 --> 00:16:20.340
<v Gary Greenberg>let's just take any adolescent and diagnose him.

372
00:16:21.200 --> 00:16:24.420
<v Gary Greenberg>So the impetus was,

373
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<v Gary Greenberg>and by the way, it's not just a problem

374
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<v Gary Greenberg>of not being taken seriously,

375
00:16:28.500 --> 00:16:30.800
<v Gary Greenberg>you know, the people who are going to take these kids seriously

376
00:16:30.800 --> 00:16:32.980
<v Gary Greenberg>were insurance companies, researchers,

377
00:16:34.280 --> 00:16:35.240
<v Gary Greenberg>other pediatricians,

378
00:16:35.240 --> 00:16:38.160
<v Gary Greenberg>the label wasn't going to attract any research.

379
00:16:38.260 --> 00:16:38.700
<v Gary Greenberg>They were going to take them as a resource.

380
00:16:39.180 --> 00:16:40.520
<v Gary Greenberg>And that was a problem.

381
00:16:40.800 --> 00:16:42.300
<v Gary Greenberg>So these people were motivated

382
00:16:42.300 --> 00:16:43.820
<v Gary Greenberg>to get these kids resources,

383
00:16:44.100 --> 00:16:46.220
<v Gary Greenberg>and they seized on bipolar disorder,

384
00:16:46.380 --> 00:16:48.300
<v Gary Greenberg>which is a very serious illness.

385
00:16:48.780 --> 00:16:50.740
<v Gary Greenberg>In its pristine form,

386
00:16:50.900 --> 00:16:53.800
<v Gary Greenberg>it's one of the most devastating mental illnesses.

387
00:16:53.880 --> 00:16:56.020
<v Gary Greenberg>It's thought to be familial, if not genetic.

388
00:16:56.240 --> 00:16:57.540
<v Gary Greenberg>It's thought to be biochemical

389
00:16:57.540 --> 00:16:59.040
<v Gary Greenberg>and unresponsive to the environment.

390
00:16:59.240 --> 00:17:00.380
<v Gary Greenberg>It's thought to be lifelong.

391
00:17:01.400 --> 00:17:04.300
<v Gary Greenberg>And, of course, the treatment for bipolar disorder

392
00:17:05.540 --> 00:17:07.660
<v Gary Greenberg>was, well, at the time,

393
00:17:07.660 --> 00:17:09.200
<v Gary Greenberg>they were called antipsychotic drugs,

394
00:17:09.360 --> 00:17:11.860
<v Gary Greenberg>but quickly, as the drug companies caught wind of this,

395
00:17:12.040 --> 00:17:14.500
<v Gary Greenberg>they were called mood stabilizers.

396
00:17:14.540 --> 00:17:16.620
<v Gary Greenberg>Same drugs, different brand.

397
00:17:19.760 --> 00:17:21.420
<v Gary Greenberg>So, and Biederman said

398
00:17:21.980 --> 00:17:23.600
<v Gary Greenberg>that childhood irritability,

399
00:17:23.680 --> 00:17:25.380
<v Gary Greenberg>to get around the episodic mania problem,

400
00:17:25.580 --> 00:17:26.980
<v Gary Greenberg>he said, childhood irritability

401
00:17:27.660 --> 00:17:30.500
<v Gary Greenberg>is the juvenile version of adult mania.

402
00:17:30.860 --> 00:17:32.760
<v Gary Greenberg>There's no reason to say that.

403
00:17:32.980 --> 00:17:34.480
<v Gary Greenberg>It doesn't make any sense.

404
00:17:34.600 --> 00:17:36.580
<v Gary Greenberg>And, in fact, there's no study that shows

405
00:17:36.580 --> 00:17:37.940
<v Gary Greenberg>that irritable children,

406
00:17:38.140 --> 00:17:39.460
<v Gary Greenberg>like the ones I described,

407
00:17:39.600 --> 00:17:40.640
<v Gary Greenberg>not your irritable children,

408
00:17:41.600 --> 00:17:43.760
<v Gary Greenberg>go on to become manic.

409
00:17:44.580 --> 00:17:47.260
<v Gary Greenberg>But if you have enough power and enough authority,

410
00:17:47.440 --> 00:17:48.760
<v Gary Greenberg>you can say this,

411
00:17:48.900 --> 00:17:50.820
<v Gary Greenberg>especially because in psychiatry,

412
00:17:50.860 --> 00:17:51.820
<v Gary Greenberg>there's no biology.

413
00:17:52.100 --> 00:17:53.340
<v Gary Greenberg>There's nothing to show.

414
00:17:53.700 --> 00:17:54.660
<v Gary Greenberg>It's rhetoric.

415
00:17:54.900 --> 00:17:56.160
<v Gary Greenberg>It's who's most persuasive.

416
00:17:56.280 --> 00:17:58.080
<v Gary Greenberg>It's who's the key opinion leader.

417
00:17:58.620 --> 00:18:01.920
<v Gary Greenberg>So Professor Biederman and his team

418
00:18:02.580 --> 00:18:04.800
<v Gary Greenberg>were able to convince their colleagues

419
00:18:04.800 --> 00:18:06.040
<v Gary Greenberg>that these kids needed

420
00:18:06.580 --> 00:18:07.700
<v Gary Greenberg>to be diagnosed with bipolar

421
00:18:07.700 --> 00:18:10.040
<v Gary Greenberg>and treated with antipsychotic drugs.

422
00:18:10.820 --> 00:18:11.700
<v Gary Greenberg>And, by the way,

423
00:18:11.780 --> 00:18:14.860
<v Gary Greenberg>he didn't have to violate anything in the DSM to do this.

424
00:18:15.020 --> 00:18:16.440
<v Gary Greenberg>Even though I've just told you, you know,

425
00:18:16.480 --> 00:18:17.920
<v Gary Greenberg>about the episodic mania requirement,

426
00:18:18.280 --> 00:18:20.200
<v Gary Greenberg>there's a trump card in the DSM.

427
00:18:20.200 --> 00:18:21.620
<v Gary Greenberg>There's two trump cards in the DSM.

428
00:18:21.700 --> 00:18:24.260
<v Gary Greenberg>It's like having an ace and a one-eye jack

429
00:18:24.260 --> 00:18:25.060
<v Gary Greenberg>at the same time.

430
00:18:25.300 --> 00:18:28.260
<v Gary Greenberg>The ace is that if the clinician thinks

431
00:18:28.260 --> 00:18:30.160
<v Gary Greenberg>that a person has a disorder,

432
00:18:30.720 --> 00:18:32.100
<v Gary Greenberg>that clinician is free,

433
00:18:32.180 --> 00:18:34.540
<v Gary Greenberg>even if the patient doesn't meet the criteria

434
00:18:34.540 --> 00:18:35.340
<v Gary Greenberg>for the disorder,

435
00:18:35.340 --> 00:18:36.380
<v Gary Greenberg>the diagnostic criteria,

436
00:18:37.060 --> 00:18:39.360
<v Gary Greenberg>the clinician is still free to make the diagnosis

437
00:18:39.360 --> 00:18:40.960
<v Gary Greenberg>if he simply thinks

438
00:18:40.960 --> 00:18:43.140
<v Gary Greenberg>they have the disorder in question.

439
00:18:43.420 --> 00:18:44.920
<v Gary Greenberg>The second ace in the hole

440
00:18:44.920 --> 00:18:50.800
<v Gary Greenberg>is that there's a little diagnostic category

441
00:18:51.340 --> 00:18:52.280
<v Gary Greenberg>called NOS,

442
00:18:52.580 --> 00:18:53.820
<v Gary Greenberg>not otherwise specified.

443
00:18:54.160 --> 00:18:55.680
<v Gary Greenberg>In the case of bipolar disorder,

444
00:18:55.900 --> 00:18:57.500
<v Gary Greenberg>bipolar disorder, NOS.

445
00:18:57.660 --> 00:18:59.940
<v Gary Greenberg>It's almost like a get-out-of-jail-free card

446
00:18:59.940 --> 00:19:00.640
<v Gary Greenberg>or something, you know.

447
00:19:00.660 --> 00:19:02.840
<v Gary Greenberg>You can just use it when you need it.

448
00:19:02.920 --> 00:19:04.120
<v Gary Greenberg>And this is what they did.

449
00:19:04.180 --> 00:19:05.140
<v Gary Greenberg>They diagnosed all these kids

450
00:19:05.140 --> 00:19:06.580
<v Gary Greenberg>with bipolar disorder, NOS.

451
00:19:07.260 --> 00:19:09.480
<v Gary Greenberg>This became an enormous epidemic.

452
00:19:09.840 --> 00:19:11.560
<v Gary Greenberg>There was a 40-fold increase

453
00:19:11.560 --> 00:19:14.600
<v Gary Greenberg>in the rates of bipolar disorder among children,

454
00:19:14.700 --> 00:19:15.840
<v Gary Greenberg>which isn't hard to imagine

455
00:19:15.840 --> 00:19:17.140
<v Gary Greenberg>because there was none.

456
00:19:17.840 --> 00:19:20.640
<v Gary Greenberg>Prior to 1998 or so,

457
00:19:20.800 --> 00:19:22.760
<v Gary Greenberg>it virtually did not exist

458
00:19:22.760 --> 00:19:24.260
<v Gary Greenberg>in the pediatric population.

459
00:19:24.760 --> 00:19:27.680
<v Gary Greenberg>And by 2007, there were half a million kids,

460
00:19:27.980 --> 00:19:29.880
<v Gary Greenberg>20,000 of them, this is in the States,

461
00:19:30.020 --> 00:19:33.280
<v Gary Greenberg>20,000 of them under the age of six

462
00:19:33.280 --> 00:19:35.120
<v Gary Greenberg>being treated with NOS.

463
00:19:35.140 --> 00:19:35.920
<v Gary Greenberg>And these kids were given antipsychotic drugs,

464
00:19:36.080 --> 00:19:38.440
<v Gary Greenberg>which had never been taken through clinical trials

465
00:19:39.140 --> 00:19:40.340
<v Gary Greenberg>with pediatric population,

466
00:19:41.260 --> 00:19:44.420
<v Gary Greenberg>had never been, like all psychiatric drugs,

467
00:19:44.520 --> 00:19:46.240
<v Gary Greenberg>the antipsychotics, nobody knows how they work.

468
00:19:46.820 --> 00:19:49.180
<v Gary Greenberg>Nobody knows what the long-term effects on the brain are.

469
00:19:49.460 --> 00:19:51.420
<v Gary Greenberg>And so these kids were given these drugs

470
00:19:51.420 --> 00:19:58.480
<v Gary Greenberg>and it was part of what made the antipsychotic drugs go

471
00:19:58.480 --> 00:20:02.000
<v Gary Greenberg>from drugs that were used essentially in the back ward

472
00:20:02.000 --> 00:20:04.360
<v Gary Greenberg>or to keep people out of the back ward.

473
00:20:04.360 --> 00:20:06.500
<v Gary Greenberg>These drugs were getting used so much

474
00:20:06.500 --> 00:20:09.600
<v Gary Greenberg>that they became the leading class of drugs

475
00:20:09.600 --> 00:20:11.700
<v Gary Greenberg>prescribed in the United States.

476
00:20:15.100 --> 00:20:17.780
<v Gary Greenberg>Now, so, you know, the bipolar express

477
00:20:18.520 --> 00:20:20.040
<v Gary Greenberg>had become a runaway train.

478
00:20:20.580 --> 00:20:23.600
<v Gary Greenberg>And this drew the attention of the United States Congress,

479
00:20:23.720 --> 00:20:25.660
<v Gary Greenberg>which once upon a time actually did something.

480
00:20:28.820 --> 00:20:31.280
<v Gary Greenberg>The Senator, Charles Grassley,

481
00:20:31.420 --> 00:20:34.340
<v Gary Greenberg>an otherwise not a guy I would necessarily remember,

482
00:20:34.360 --> 00:20:34.660
<v Gary Greenberg>but I would relate to,

483
00:20:35.880 --> 00:20:38.320
<v Gary Greenberg>he decided that the ties between medicine

484
00:20:38.320 --> 00:20:42.620
<v Gary Greenberg>and pharmaceutical companies were too tight.

485
00:20:43.180 --> 00:20:45.480
<v Gary Greenberg>And there was no better place to look for this

486
00:20:45.480 --> 00:20:46.980
<v Gary Greenberg>than in psychiatry.

487
00:20:47.860 --> 00:20:50.520
<v Gary Greenberg>Psychiatrists make less money than most doctors in America.

488
00:20:50.680 --> 00:20:54.040
<v Gary Greenberg>They can only, their average income is only around 200 grand a year.

489
00:20:54.440 --> 00:20:57.620
<v Gary Greenberg>So they're more likely to supplement by working for drug companies.

490
00:20:57.740 --> 00:20:58.560
<v Gary Greenberg>But more to the point,

491
00:20:59.600 --> 00:21:01.920
<v Gary Greenberg>psychiatric diagnoses, as I've just illustrated,

492
00:21:02.120 --> 00:21:03.380
<v Gary Greenberg>are infinitely malleable.

493
00:21:04.360 --> 00:21:06.220
<v Gary Greenberg>So they're very interesting to drug companies.

494
00:21:07.280 --> 00:21:09.880
<v Gary Greenberg>Well, it turned out, he subpoenaed Biederman.

495
00:21:10.240 --> 00:21:13.020
<v Gary Greenberg>And it turned out that Biederman had been getting paid

496
00:21:13.700 --> 00:21:16.220
<v Gary Greenberg>by Johnson & Johnson, which makes Risperidol,

497
00:21:16.320 --> 00:21:17.720
<v Gary Greenberg>which is one of the antipsychotic drugs.

498
00:21:18.380 --> 00:21:20.900
<v Gary Greenberg>He'd collected $1.6 million from them

499
00:21:21.860 --> 00:21:24.840
<v Gary Greenberg>in the last two years before the subpoena came out.

500
00:21:25.020 --> 00:21:27.460
<v Gary Greenberg>And he hadn't disclosed it to Harvard University.

501
00:21:28.680 --> 00:21:31.220
<v Gary Greenberg>Now, Biederman was a guy, he was a fighter.

502
00:21:31.520 --> 00:21:33.000
<v Gary Greenberg>He was the kind of guy who,

503
00:21:33.000 --> 00:21:34.880
<v Gary Greenberg>when people attacked him in writing,

504
00:21:35.040 --> 00:21:39.040
<v Gary Greenberg>he would compare them to the Pope and himself to Galileo.

505
00:21:39.600 --> 00:21:41.520
<v Gary Greenberg>He compared himself to Edward Jenner,

506
00:21:41.640 --> 00:21:44.120
<v Gary Greenberg>the guy who originated the smallpox vaccine.

507
00:21:45.900 --> 00:21:48.980
<v Gary Greenberg>He, on testimony,

508
00:21:49.780 --> 00:21:51.360
<v Gary Greenberg>his lawyer asked him,

509
00:21:51.460 --> 00:21:54.240
<v Gary Greenberg>can you tell us what your place is at Harvard?

510
00:21:54.340 --> 00:21:55.620
<v Gary Greenberg>He said, I'm a full professor at Harvard.

511
00:21:55.800 --> 00:21:58.720
<v Gary Greenberg>And the lawyer, I think hoping to establish how important that was, said,

512
00:21:58.800 --> 00:21:59.860
<v Gary Greenberg>and what comes after that?

513
00:21:59.960 --> 00:22:00.860
<v Gary Greenberg>And Biederman said, God.

514
00:22:01.980 --> 00:22:02.980
<v Gary Greenberg>And his lawyer said,

515
00:22:02.980 --> 00:22:04.060
<v Gary Greenberg>how's that again?

516
00:22:04.320 --> 00:22:05.300
<v Gary Greenberg>And Biederman said,

517
00:22:05.940 --> 00:22:07.420
<v Gary Greenberg>he said, actually, did you say God?

518
00:22:07.660 --> 00:22:08.980
<v Gary Greenberg>And Biederman said, yeah.

519
00:22:09.460 --> 00:22:11.540
<v Gary Greenberg>Which are really interesting comments from somebody

520
00:22:11.540 --> 00:22:13.300
<v Gary Greenberg>who's very interested in bipolar disorder,

521
00:22:13.500 --> 00:22:16.360
<v Gary Greenberg>one of whose criteria is delusions of grandeur.

522
00:22:18.980 --> 00:22:21.660
<v Gary Greenberg>But, you know, to be fair, I guess, to Dr. Biederman,

523
00:22:21.740 --> 00:22:24.460
<v Gary Greenberg>I don't want to be diagnosing him even from 12,000 miles away

524
00:22:24.460 --> 00:22:25.540
<v Gary Greenberg>or however far away I am.

525
00:22:25.600 --> 00:22:26.720
<v Gary Greenberg>I've lost track at this point.

526
00:22:27.320 --> 00:22:30.760
<v Gary Greenberg>I do want to say that regardless of that motivation,

527
00:22:31.080 --> 00:22:32.960
<v Gary Greenberg>it was clear that Biederman,

528
00:22:32.980 --> 00:22:35.280
<v Gary Greenberg>that there was something unsavory going on there.

529
00:22:37.060 --> 00:22:39.980
<v Gary Greenberg>That, and Harvard decided there was too.

530
00:22:40.140 --> 00:22:41.200
<v Gary Greenberg>They actually punished him.

531
00:22:41.240 --> 00:22:43.500
<v Gary Greenberg>They said he couldn't have any industry contracts for one year.

532
00:22:44.320 --> 00:22:49.020
<v Gary Greenberg>They also said that he had to get their approval for outside work for two years.

533
00:22:49.620 --> 00:22:52.240
<v Gary Greenberg>And then they said he couldn't ever be considered for promotion,

534
00:22:52.360 --> 00:22:53.020
<v Gary Greenberg>I assume to God.

535
00:22:53.520 --> 00:22:56.500
<v Gary Greenberg>But even Harvard can't do that.

536
00:22:57.360 --> 00:22:59.080
<v Gary Greenberg>Now, obviously, this is corruption.

537
00:22:59.840 --> 00:23:01.620
<v Gary Greenberg>But what kind of corruption is it?

538
00:23:02.160 --> 00:23:03.460
<v Gary Greenberg>Do we really want to believe?

539
00:23:03.640 --> 00:23:04.240
<v Gary Greenberg>And we'll never know.

540
00:23:04.400 --> 00:23:05.180
<v Gary Greenberg>That Biederman was, you know,

541
00:23:05.180 --> 00:23:07.860
<v Gary Greenberg>quid pro quo, I'll pay you and you get us so many patients.

542
00:23:08.520 --> 00:23:09.760
<v Gary Greenberg>I actually don't think so.

543
00:23:09.920 --> 00:23:10.760
<v Gary Greenberg>I don't know the guy.

544
00:23:11.080 --> 00:23:12.340
<v Gary Greenberg>Give him the benefit of the doubt.

545
00:23:12.440 --> 00:23:13.720
<v Gary Greenberg>I don't think that's what it was at all.

546
00:23:14.080 --> 00:23:16.220
<v Gary Greenberg>I think he saw Johnson & Johnson as patrons

547
00:23:16.220 --> 00:23:19.220
<v Gary Greenberg>in the same way that artists saw the Medicis as patrons.

548
00:23:19.380 --> 00:23:20.800
<v Gary Greenberg>I mean, that's a really sick comparison.

549
00:23:21.080 --> 00:23:21.840
<v Gary Greenberg>But you know what I'm saying.

550
00:23:22.060 --> 00:23:27.320
<v Gary Greenberg>You have a convergence of interests.

551
00:23:28.200 --> 00:23:29.840
<v Gary Greenberg>Maybe even a deal with the devil.

552
00:23:29.960 --> 00:23:30.960
<v Gary Greenberg>I don't really think so.

553
00:23:30.960 --> 00:23:32.480
<v Gary Greenberg>But you know, the point is,

554
00:23:32.500 --> 00:23:33.980
<v Gary Greenberg>he didn't have to get paid off

555
00:23:34.520 --> 00:23:36.660
<v Gary Greenberg>because he already believed in the model.

556
00:23:36.960 --> 00:23:38.600
<v Gary Greenberg>And so did Johnson & Johnson.

557
00:23:38.900 --> 00:23:40.000
<v Gary Greenberg>They were buddies.

558
00:23:40.320 --> 00:23:42.740
<v Gary Greenberg>They were intellectual fellow travelers.

559
00:23:43.200 --> 00:23:45.760
<v Gary Greenberg>And this is an intellectual form of corruption.

560
00:23:45.880 --> 00:23:48.300
<v Gary Greenberg>And it revolves around the unquestioned assumption

561
00:23:48.960 --> 00:23:50.740
<v Gary Greenberg>that everyone who is crazy is sick.

562
00:23:51.600 --> 00:23:53.440
<v Gary Greenberg>So you see, all diseases are markets.

563
00:23:53.760 --> 00:23:57.080
<v Gary Greenberg>You don't need conspiracies when you have capitalism.

564
00:23:57.760 --> 00:24:00.440
<v Gary Greenberg>Because capitalism is the biggest conspiracy of all.

565
00:24:01.120 --> 00:24:03.120
<v Gary Greenberg>And probably now I sound paranoid.

566
00:24:03.380 --> 00:24:05.860
<v Gary Greenberg>But you save your diagnoses for later.

567
00:24:06.640 --> 00:24:10.380
<v Gary Greenberg>So the question I want to talk a little bit about now,

568
00:24:10.600 --> 00:24:14.180
<v Gary Greenberg>that I've established that we have to look at this historically,

569
00:24:14.400 --> 00:24:15.700
<v Gary Greenberg>and the history I want to talk about

570
00:24:15.700 --> 00:24:17.380
<v Gary Greenberg>is the history of this idea

571
00:24:18.200 --> 00:24:19.720
<v Gary Greenberg>that craziness is illness.

572
00:24:20.580 --> 00:24:24.660
<v Gary Greenberg>It actually goes back to the discovery of germs.

573
00:24:25.660 --> 00:24:27.460
<v Gary Greenberg>In the middle of the 19th century,

574
00:24:29.500 --> 00:24:31.100
<v Gary Greenberg>medicine changed completely.

575
00:24:31.420 --> 00:24:33.540
<v Gary Greenberg>I don't know if we're aware enough,

576
00:24:33.600 --> 00:24:34.660
<v Gary Greenberg>on a day-to-day basis,

577
00:24:34.880 --> 00:24:37.000
<v Gary Greenberg>of how our notions of sickness and health,

578
00:24:37.180 --> 00:24:40.140
<v Gary Greenberg>life and death, suffering and relief,

579
00:24:40.400 --> 00:24:42.840
<v Gary Greenberg>were changed 150 years ago.

580
00:24:42.880 --> 00:24:44.080
<v Gary Greenberg>We see it completely differently

581
00:24:44.080 --> 00:24:47.160
<v Gary Greenberg>from the way people would have in the 1700s.

582
00:24:47.200 --> 00:24:49.320
<v Gary Greenberg>What happened was, germs were discovered.

583
00:24:50.440 --> 00:24:52.460
<v Gary Greenberg>And with the discovery of germs,

584
00:24:52.720 --> 00:24:55.300
<v Gary Greenberg>and by the way, germs were discovered contemporaneously

585
00:24:55.300 --> 00:24:56.460
<v Gary Greenberg>with the chemical

586
00:24:56.680 --> 00:24:58.240
<v Gary Greenberg>that would treat them.

587
00:24:58.500 --> 00:25:00.020
<v Gary Greenberg>There's a very interesting story.

588
00:25:01.600 --> 00:25:04.540
<v Gary Greenberg>The dye, the purple dye, called mauve,

589
00:25:04.660 --> 00:25:07.200
<v Gary Greenberg>was discovered by a guy

590
00:25:07.200 --> 00:25:09.340
<v Gary Greenberg>who was trying to figure out what to do with coal tar.

591
00:25:09.560 --> 00:25:10.860
<v Gary Greenberg>This is how weird this gets.

592
00:25:11.560 --> 00:25:12.740
<v Gary Greenberg>Coal tar was a problem.

593
00:25:12.900 --> 00:25:15.700
<v Gary Greenberg>It was the residue of the refining of gas

594
00:25:15.700 --> 00:25:17.520
<v Gary Greenberg>that was used to light the lamps in London.

595
00:25:17.660 --> 00:25:19.240
<v Gary Greenberg>And it was polluting the city.

596
00:25:19.320 --> 00:25:20.780
<v Gary Greenberg>This is in the early 19th century.

597
00:25:21.040 --> 00:25:22.920
<v Gary Greenberg>And they wondered, what are we going to do with that stuff?

598
00:25:23.180 --> 00:25:24.100
<v Gary Greenberg>It's all over the place.

599
00:25:24.140 --> 00:25:25.800
<v Gary Greenberg>I don't know if you know the Dr. Seuss book,

600
00:25:25.880 --> 00:25:26.660
<v Gary Greenberg>Bartholomew and the

601
00:25:26.680 --> 00:25:27.160
<v Gary Greenberg>Oobleck.

602
00:25:27.260 --> 00:25:29.340
<v Gary Greenberg>Well, Oobleck is the coal tar.

603
00:25:29.460 --> 00:25:29.800
<v Gary Greenberg>Everywhere.

604
00:25:30.040 --> 00:25:31.860
<v Gary Greenberg>The rivers, in people's clothes,

605
00:25:32.420 --> 00:25:33.680
<v Gary Greenberg>in the drinking water.

606
00:25:34.320 --> 00:25:37.240
<v Gary Greenberg>And the only thing that had gotten done with it so far

607
00:25:37.240 --> 00:25:38.800
<v Gary Greenberg>was that a guy named Macintosh

608
00:25:38.800 --> 00:25:42.040
<v Gary Greenberg>had turned it into a rubberizing application

609
00:25:42.040 --> 00:25:42.980
<v Gary Greenberg>to put on cloth.

610
00:25:43.220 --> 00:25:45.080
<v Gary Greenberg>And that's where the Macintosh raincoat came from.

611
00:25:45.680 --> 00:25:47.480
<v Gary Greenberg>Perkin, William Perkin was his name,

612
00:25:47.540 --> 00:25:49.960
<v Gary Greenberg>a young chemist, by accident found

613
00:25:50.540 --> 00:25:53.100
<v Gary Greenberg>that you could turn this coal tar

614
00:25:53.680 --> 00:25:56.640
<v Gary Greenberg>into a deep purple dye called mauve.

615
00:25:56.680 --> 00:26:00.880
<v Gary Greenberg>And the reason that Perkin was playing with coal tar

616
00:26:00.880 --> 00:26:02.320
<v Gary Greenberg>was because he was an organic chemist

617
00:26:02.320 --> 00:26:04.120
<v Gary Greenberg>and he had found that,

618
00:26:04.220 --> 00:26:05.680
<v Gary Greenberg>organic chemists had found,

619
00:26:05.840 --> 00:26:07.820
<v Gary Greenberg>that coal tar, like us,

620
00:26:08.100 --> 00:26:10.800
<v Gary Greenberg>is made out of carbon, nitrogen, and oxygen, and hydrogen.

621
00:26:11.020 --> 00:26:12.580
<v Gary Greenberg>And the question was before us,

622
00:26:12.660 --> 00:26:14.100
<v Gary Greenberg>can we synthesize?

623
00:26:14.560 --> 00:26:16.060
<v Gary Greenberg>Can we synthesize life?

624
00:26:16.980 --> 00:26:20.180
<v Gary Greenberg>1824 is when Perkin developed mauve.

625
00:26:20.260 --> 00:26:23.140
<v Gary Greenberg>I think Frankenstein was maybe ten years prior.

626
00:26:23.420 --> 00:26:26.520
<v Gary Greenberg>The idea that we could create life was on people's minds.

627
00:26:26.680 --> 00:26:28.140
<v Gary Greenberg>And the idea that it could be done

628
00:26:28.140 --> 00:26:30.920
<v Gary Greenberg>with these very simple chemicals was on people's minds.

629
00:26:31.100 --> 00:26:35.500
<v Gary Greenberg>And eventually, that idea became the idea

630
00:26:35.500 --> 00:26:38.200
<v Gary Greenberg>that we can take those chemicals, those compounds,

631
00:26:39.060 --> 00:26:41.180
<v Gary Greenberg>and we can turn them into drugs.

632
00:26:41.340 --> 00:26:43.560
<v Gary Greenberg>The first drugs were dyes.

633
00:26:44.680 --> 00:26:48.780
<v Gary Greenberg>That's why, if you look at the history of Bayer, and Merck, and Hoechst,

634
00:26:48.840 --> 00:26:51.420
<v Gary Greenberg>and the big German pharmaceutical companies,

635
00:26:51.540 --> 00:26:53.940
<v Gary Greenberg>you'll find that in their earlier years, they were dye companies.

636
00:26:54.660 --> 00:26:56.520
<v Gary Greenberg>Because what was once

637
00:26:56.680 --> 00:26:58.940
<v Gary Greenberg>thought just to be able to color clothing,

638
00:26:59.120 --> 00:27:02.300
<v Gary Greenberg>it turned out that those chains of molecules

639
00:27:02.900 --> 00:27:06.100
<v Gary Greenberg>could be joined to the molecules of the germs

640
00:27:06.100 --> 00:27:07.040
<v Gary Greenberg>that were being discovered,

641
00:27:07.920 --> 00:27:09.020
<v Gary Greenberg>and could kill them.

642
00:27:09.520 --> 00:27:12.280
<v Gary Greenberg>The fellow who first figured this out, Paul Ehrlich,

643
00:27:12.480 --> 00:27:13.660
<v Gary Greenberg>called them magic bullets.

644
00:27:14.620 --> 00:27:18.320
<v Gary Greenberg>And he had discovered this because he was uniquely interested.

645
00:27:19.240 --> 00:27:21.020
<v Gary Greenberg>Biologists were happy to have these dyes.

646
00:27:21.180 --> 00:27:22.760
<v Gary Greenberg>They could look under their microscope,

647
00:27:22.820 --> 00:27:25.200
<v Gary Greenberg>and they could see the cell in a way

648
00:27:25.200 --> 00:27:26.520
<v Gary Greenberg>that had never been seen before.

649
00:27:26.780 --> 00:27:29.620
<v Gary Greenberg>There was the ability to see the mitochondria,

650
00:27:29.640 --> 00:27:31.020
<v Gary Greenberg>and they were lit up in different colors.

651
00:27:31.220 --> 00:27:33.380
<v Gary Greenberg>And they were so thrilled to see this, that nobody stopped to ask,

652
00:27:33.420 --> 00:27:34.440
<v Gary Greenberg>I wonder why the hell that's happening?

653
00:27:35.000 --> 00:27:35.960
<v Gary Greenberg>Except Paul Ehrlich.

654
00:27:36.180 --> 00:27:37.260
<v Gary Greenberg>And he looked at it, and he said,

655
00:27:37.280 --> 00:27:39.100
<v Gary Greenberg>you know, the different chemical structure

656
00:27:39.100 --> 00:27:41.560
<v Gary Greenberg>of those different parts of the cell

657
00:27:42.200 --> 00:27:45.340
<v Gary Greenberg>must link up differently with the dye.

658
00:27:46.620 --> 00:27:48.860
<v Gary Greenberg>And that was the insight that led him to think

659
00:27:48.860 --> 00:27:52.980
<v Gary Greenberg>that maybe he could get those chemicals, those dyes,

660
00:27:53.000 --> 00:27:55.180
<v Gary Greenberg>to link up with the dye.

661
00:27:55.200 --> 00:27:56.700
<v Gary Greenberg>The germs, and kill them.

662
00:27:57.120 --> 00:27:58.980
<v Gary Greenberg>And it turned out he was right.

663
00:27:59.360 --> 00:28:01.860
<v Gary Greenberg>And the first drug that he developed,

664
00:28:02.000 --> 00:28:03.000
<v Gary Greenberg>which was in 1906,

665
00:28:03.380 --> 00:28:05.600
<v Gary Greenberg>he had to go to his company, he was working for a dye company,

666
00:28:05.820 --> 00:28:08.580
<v Gary Greenberg>and convince them to, you know, set him loose on this project,

667
00:28:08.980 --> 00:28:10.700
<v Gary Greenberg>was a drug called salversan,

668
00:28:10.840 --> 00:28:13.100
<v Gary Greenberg>which was aimed at syphilis.

669
00:28:14.600 --> 00:28:16.720
<v Gary Greenberg>And it wasn't such a good syphilis drug,

670
00:28:16.800 --> 00:28:19.180
<v Gary Greenberg>but a few years later, penicillin was discovered,

671
00:28:19.340 --> 00:28:21.160
<v Gary Greenberg>which once they figured out how to mass produce it,

672
00:28:21.200 --> 00:28:23.020
<v Gary Greenberg>was a tremendous syphilis drug.

673
00:28:23.940 --> 00:28:26.380
<v Gary Greenberg>You can go out and get syphilis now, and you don't die.

674
00:28:26.600 --> 00:28:29.320
<v Gary Greenberg>Now, interesting side note about syphilis.

675
00:28:29.440 --> 00:28:30.980
<v Gary Greenberg>At the turn of the 20th century,

676
00:28:31.540 --> 00:28:34.420
<v Gary Greenberg>somewhere between a third and maybe a half of the inmates

677
00:28:34.420 --> 00:28:38.340
<v Gary Greenberg>of insane asylums in Europe had syphilis.

678
00:28:38.960 --> 00:28:42.160
<v Gary Greenberg>Because syphilis, in its tertiary manifestation,

679
00:28:42.980 --> 00:28:44.920
<v Gary Greenberg>the spirochete gets into the brain.

680
00:28:46.440 --> 00:28:49.060
<v Gary Greenberg>So, the discovery of these drugs,

681
00:28:49.360 --> 00:28:51.120
<v Gary Greenberg>and now I'm going to come back to psychiatry,

682
00:28:51.160 --> 00:28:51.620
<v Gary Greenberg>because you're all wondering,

683
00:28:51.620 --> 00:28:52.980
<v Gary Greenberg>what the hell is he talking about this stuff for?

684
00:28:53.200 --> 00:28:55.680
<v Gary Greenberg>Because the discovery of these drugs

685
00:28:56.780 --> 00:28:59.920
<v Gary Greenberg>changed forever what we expect of doctors.

686
00:29:00.320 --> 00:29:03.280
<v Gary Greenberg>It changed how we understand suffering.

687
00:29:03.660 --> 00:29:08.620
<v Gary Greenberg>It changed what we think our lives can be.

688
00:29:08.860 --> 00:29:11.280
<v Gary Greenberg>Because now, when you get strep throat,

689
00:29:11.520 --> 00:29:13.100
<v Gary Greenberg>or when your child gets strep throat,

690
00:29:13.340 --> 00:29:15.180
<v Gary Greenberg>you don't have to worry that your child's going to die,

691
00:29:15.360 --> 00:29:16.720
<v Gary Greenberg>which people used to.

692
00:29:16.940 --> 00:29:19.340
<v Gary Greenberg>And people in countries without antibiotics do.

693
00:29:20.060 --> 00:29:21.520
<v Gary Greenberg>Now, when you have,

694
00:29:21.620 --> 00:29:23.480
<v Gary Greenberg>if you're unfortunate enough to have type 1 diabetes,

695
00:29:24.180 --> 00:29:25.000
<v Gary Greenberg>there's insulin.

696
00:29:25.780 --> 00:29:28.260
<v Gary Greenberg>Now, if you have an inflammatory disease

697
00:29:28.260 --> 00:29:29.320
<v Gary Greenberg>that's at least short-lived,

698
00:29:29.460 --> 00:29:30.720
<v Gary Greenberg>you can take cortisone.

699
00:29:30.920 --> 00:29:32.500
<v Gary Greenberg>These were tremendous discoveries.

700
00:29:32.960 --> 00:29:34.960
<v Gary Greenberg>And they gave rise to an expectation

701
00:29:35.620 --> 00:29:39.780
<v Gary Greenberg>that suffering could be targeted and cured.

702
00:29:41.080 --> 00:29:41.620
<v Gary Greenberg>Scientifically,

703
00:29:42.620 --> 00:29:44.220
<v Gary Greenberg>these were things that could be seen under the microscope.

704
00:29:45.320 --> 00:29:47.800
<v Gary Greenberg>The temptation to turn all of our suffering

705
00:29:48.620 --> 00:29:50.180
<v Gary Greenberg>into that kind of a problem,

706
00:29:50.820 --> 00:29:53.860
<v Gary Greenberg>and I call it a temptation because it's not just the doctors

707
00:29:53.860 --> 00:29:54.600
<v Gary Greenberg>and the drug companies.

708
00:29:54.740 --> 00:29:56.660
<v Gary Greenberg>I mean, yeah, they're working their side of it.

709
00:29:56.740 --> 00:29:57.960
<v Gary Greenberg>But we all want that.

710
00:29:58.040 --> 00:29:58.960
<v Gary Greenberg>Who doesn't want that?

711
00:29:59.540 --> 00:30:02.720
<v Gary Greenberg>You know, the idea that if you wake up in the middle of the night

712
00:30:02.720 --> 00:30:03.440
<v Gary Greenberg>in a state of dread,

713
00:30:03.580 --> 00:30:05.420
<v Gary Greenberg>there would be a nice quick way to take care of that,

714
00:30:06.180 --> 00:30:08.200
<v Gary Greenberg>it's hard to argue with that.

715
00:30:08.460 --> 00:30:10.980
<v Gary Greenberg>The problem when it comes to the mind, however,

716
00:30:11.500 --> 00:30:13.240
<v Gary Greenberg>is that that's the mind,

717
00:30:13.340 --> 00:30:15.120
<v Gary Greenberg>to the extent that it's dependent on the brain,

718
00:30:15.260 --> 00:30:16.960
<v Gary Greenberg>and we could argue about this at another time,

719
00:30:17.120 --> 00:30:20.000
<v Gary Greenberg>but it's at least somewhat dependent on the brain.

720
00:30:20.000 --> 00:30:22.420
<v Gary Greenberg>If the brain is the organ of the mind,

721
00:30:22.520 --> 00:30:25.360
<v Gary Greenberg>doctors didn't have anywhere near the ability

722
00:30:25.360 --> 00:30:27.720
<v Gary Greenberg>to understand the problems of the brain

723
00:30:27.720 --> 00:30:31.560
<v Gary Greenberg>the way they could understand the problems of the blood

724
00:30:31.560 --> 00:30:33.240
<v Gary Greenberg>or the other organs.

725
00:30:33.900 --> 00:30:37.280
<v Gary Greenberg>And so psychiatry was being left behind.

726
00:30:39.500 --> 00:30:41.700
<v Gary Greenberg>Psychiatry alone among the medical professions

727
00:30:42.520 --> 00:30:45.620
<v Gary Greenberg>didn't have access to these biological markers.

728
00:30:45.920 --> 00:30:49.020
<v Gary Greenberg>And this has been a problem from psychiatrists' point of view,

729
00:30:49.020 --> 00:30:51.500
<v Gary Greenberg>as long as there's been psychiatry,

730
00:30:51.520 --> 00:30:55.040
<v Gary Greenberg>because psychiatry also arose in the middle of the 19th century.

731
00:30:57.380 --> 00:31:00.920
<v Gary Greenberg>And lagging behind didn't stop psychiatrists

732
00:31:00.920 --> 00:31:02.400
<v Gary Greenberg>from trying to develop their profession.

733
00:31:02.720 --> 00:31:06.100
<v Gary Greenberg>Indeed, in the 1920s, 1910s, 1920s,

734
00:31:06.120 --> 00:31:08.220
<v Gary Greenberg>psychiatrists expanded their domain,

735
00:31:08.940 --> 00:31:12.460
<v Gary Greenberg>not just to treat people in the insane asylums,

736
00:31:12.600 --> 00:31:16.360
<v Gary Greenberg>what were then begun to be called mental hospitals,

737
00:31:16.560 --> 00:31:19.000
<v Gary Greenberg>but to expand their domain

738
00:31:19.020 --> 00:31:21.060
<v Gary Greenberg>to treat the worried well.

739
00:31:21.600 --> 00:31:25.560
<v Gary Greenberg>The problem was that all they could go on was descriptions.

740
00:31:26.320 --> 00:31:27.840
<v Gary Greenberg>All they could say was,

741
00:31:28.020 --> 00:31:30.320
<v Gary Greenberg>well, we know what your suffering looks like,

742
00:31:30.960 --> 00:31:32.760
<v Gary Greenberg>and we're going to put a name to it.

743
00:31:34.080 --> 00:31:37.460
<v Gary Greenberg>And in the 1920s, they didn't really have names for it.

744
00:31:37.940 --> 00:31:41.780
<v Gary Greenberg>In the 1920s, there were maybe 7 or 10 or 14 or 20

745
00:31:42.440 --> 00:31:44.120
<v Gary Greenberg>named psychiatric disorders.

746
00:31:46.160 --> 00:31:48.000
<v Gary Greenberg>But the absence of biology,

747
00:31:49.400 --> 00:31:51.800
<v Gary Greenberg>didn't stop psychiatry from getting big.

748
00:31:52.120 --> 00:31:54.260
<v Gary Greenberg>Partly, it was helped out by psychoanalysis,

749
00:31:54.340 --> 00:31:55.980
<v Gary Greenberg>which stepped in to the breach

750
00:31:55.980 --> 00:31:58.700
<v Gary Greenberg>and treated the mind without respect to biology.

751
00:31:59.160 --> 00:32:02.080
<v Gary Greenberg>But all the time that psychoanalysis was controlling

752
00:32:02.080 --> 00:32:04.320
<v Gary Greenberg>our understanding of the suffering of the mind,

753
00:32:04.460 --> 00:32:05.700
<v Gary Greenberg>something else was happening.

754
00:32:06.300 --> 00:32:09.560
<v Gary Greenberg>And that was biological psychiatry.

755
00:32:10.620 --> 00:32:12.580
<v Gary Greenberg>Biological psychiatry never really went away,

756
00:32:12.680 --> 00:32:15.360
<v Gary Greenberg>but it originated, for all intents and purposes,

757
00:32:15.440 --> 00:32:17.720
<v Gary Greenberg>in the 1930s with treatments like lobotomy,

758
00:32:18.140 --> 00:32:19.300
<v Gary Greenberg>which I'm sure you've all heard of.

759
00:32:19.320 --> 00:32:22.060
<v Gary Greenberg>You know the guy that invented the frontal lobotomy,

760
00:32:22.120 --> 00:32:23.260
<v Gary Greenberg>won the Nobel Prize for it?

761
00:32:24.740 --> 00:32:26.440
<v Gary Greenberg>So this is a really interesting thing.

762
00:32:26.520 --> 00:32:27.660
<v Gary Greenberg>I'm going to digress for a second,

763
00:32:27.720 --> 00:32:29.080
<v Gary Greenberg>because it's really important to understand this.

764
00:32:29.440 --> 00:32:30.880
<v Gary Greenberg>They didn't give him the Nobel Prize

765
00:32:31.720 --> 00:32:34.680
<v Gary Greenberg>because they didn't think it was a good idea, the lobotomy.

766
00:32:35.460 --> 00:32:37.280
<v Gary Greenberg>They gave him the Nobel Prize

767
00:32:37.280 --> 00:32:38.460
<v Gary Greenberg>because they thought he was helping people.

768
00:32:38.560 --> 00:32:40.500
<v Gary Greenberg>He was helping people in some way. He had to be.

769
00:32:41.080 --> 00:32:42.280
<v Gary Greenberg>They gave him the Nobel Prize

770
00:32:42.280 --> 00:32:44.660
<v Gary Greenberg>because they thought he'd done something wonderful.

771
00:32:45.560 --> 00:32:46.920
<v Gary Greenberg>And the reason I say that now,

772
00:32:46.920 --> 00:32:49.840
<v Gary Greenberg>is because we have to think about how they're going to look back at us

773
00:32:49.840 --> 00:32:54.320
<v Gary Greenberg>150 years from now, or 50 years from now,

774
00:32:54.420 --> 00:32:57.480
<v Gary Greenberg>when they look at the pharmacological era.

775
00:32:57.760 --> 00:32:59.500
<v Gary Greenberg>So that's the next thing I want to talk about.

776
00:32:59.560 --> 00:33:01.200
<v Gary Greenberg>We've got this need for magic bullets,

777
00:33:02.000 --> 00:33:05.460
<v Gary Greenberg>we've got the ever-present human suffering of the mind,

778
00:33:05.600 --> 00:33:09.760
<v Gary Greenberg>and we've got a profession that would really like to have magic bullets

779
00:33:09.760 --> 00:33:11.800
<v Gary Greenberg>to treat that suffering.

780
00:33:11.980 --> 00:33:13.060
<v Gary Greenberg>But it can't.

781
00:33:13.520 --> 00:33:16.900
<v Gary Greenberg>And biological psychiatry in the 1950s morphed.

782
00:33:17.360 --> 00:33:21.000
<v Gary Greenberg>It was no longer treatments like lobotomy or shock therapies,

783
00:33:21.200 --> 00:33:22.440
<v Gary Greenberg>which also originated then.

784
00:33:22.700 --> 00:33:24.380
<v Gary Greenberg>And shock, by the way, wasn't just electric shock.

785
00:33:24.480 --> 00:33:27.220
<v Gary Greenberg>They put people into insulin shock, which really must have been unpleasant,

786
00:33:28.300 --> 00:33:29.980
<v Gary Greenberg>and cold ice baths.

787
00:33:29.980 --> 00:33:32.820
<v Gary Greenberg>And one day they were putting some people into cold ice baths

788
00:33:32.820 --> 00:33:35.680
<v Gary Greenberg>and treating them with an adjunct called Thorazine.

789
00:33:36.400 --> 00:33:37.840
<v Gary Greenberg>And they ran out of ice.

790
00:33:38.960 --> 00:33:39.860
<v Gary Greenberg>And the nurses said,

791
00:33:39.920 --> 00:33:41.240
<v Gary Greenberg>OK, let's just try it without the ice.

792
00:33:42.200 --> 00:33:43.160
<v Gary Greenberg>This is in France.

793
00:33:44.200 --> 00:33:46.620
<v Gary Greenberg>And the patients calmed down anyway.

794
00:33:46.620 --> 00:33:48.180
<v Gary Greenberg>They thought, oh, well, we'll save money on ice.

795
00:33:48.260 --> 00:33:49.200
<v Gary Greenberg>We'll just give them Thorazine.

796
00:33:49.600 --> 00:33:51.500
<v Gary Greenberg>A little later, this was in 1954,

797
00:33:52.400 --> 00:33:55.920
<v Gary Greenberg>another antihistamine called Imipramine was given to schizophrenics

798
00:33:55.920 --> 00:33:58.060
<v Gary Greenberg>because now the word was out, hey, we can give them these drugs,

799
00:33:58.860 --> 00:34:01.260
<v Gary Greenberg>and they'll calm down.

800
00:34:01.360 --> 00:34:03.700
<v Gary Greenberg>They gave another antihistamine to schizophrenics,

801
00:34:03.720 --> 00:34:05.500
<v Gary Greenberg>and it agitated them.

802
00:34:05.560 --> 00:34:09.080
<v Gary Greenberg>In fact, one of them rode out of the mental hospital on his bicycle

803
00:34:09.080 --> 00:34:11.300
<v Gary Greenberg>in a nightshirt and went into the town

804
00:34:11.300 --> 00:34:14.240
<v Gary Greenberg>and scandalized the mental hospital

805
00:34:14.240 --> 00:34:16.020
<v Gary Greenberg>and got the superintendent fired.

806
00:34:16.620 --> 00:34:19.300
<v Gary Greenberg>However, they didn't stop them from continuing to research this.

807
00:34:19.440 --> 00:34:22.920
<v Gary Greenberg>And they thought, well, if it agitates, stimulates schizophrenics,

808
00:34:22.980 --> 00:34:24.320
<v Gary Greenberg>what will it do to depressed people?

809
00:34:24.940 --> 00:34:27.220
<v Gary Greenberg>And it turned out it made depressed people happier.

810
00:34:28.280 --> 00:34:35.880
<v Gary Greenberg>And so the age of giving people drugs that were effective began in the 1950s.

811
00:34:35.900 --> 00:34:37.260
<v Gary Greenberg>Now, here's the important thing.

812
00:34:37.520 --> 00:34:39.260
<v Gary Greenberg>Nobody knew why these drugs worked.

813
00:34:40.300 --> 00:34:41.740
<v Gary Greenberg>Nobody understood what they did.

814
00:34:41.960 --> 00:34:43.780
<v Gary Greenberg>And when I say nobody, I mean nobody.

815
00:34:44.020 --> 00:34:45.700
<v Gary Greenberg>They had some vague idea.

816
00:34:46.620 --> 00:34:50.020
<v Gary Greenberg>Which came up in the 1950s that the brain had worked by chemistry,

817
00:34:50.320 --> 00:34:56.300
<v Gary Greenberg>that it was a chemical factory, really.

818
00:34:56.480 --> 00:34:58.300
<v Gary Greenberg>But they really didn't know what chemicals,

819
00:34:58.500 --> 00:35:00.440
<v Gary Greenberg>they didn't know how the drugs affected the chemicals,

820
00:35:00.660 --> 00:35:02.140
<v Gary Greenberg>they didn't know anything.

821
00:35:02.920 --> 00:35:05.880
<v Gary Greenberg>It wasn't until ten years later, 1965,

822
00:35:06.380 --> 00:35:08.600
<v Gary Greenberg>that somebody finally advanced a theory.

823
00:35:09.120 --> 00:35:13.720
<v Gary Greenberg>The theory was that these drugs were interfering with the metabolism

824
00:35:13.720 --> 00:35:16.080
<v Gary Greenberg>of two brain chemicals, dopamine,

825
00:35:16.620 --> 00:35:17.480
<v Gary Greenberg>and norepinephrine.

826
00:35:17.800 --> 00:35:20.200
<v Gary Greenberg>Now, this wasn't true.

827
00:35:20.500 --> 00:35:21.660
<v Gary Greenberg>This was a mistake.

828
00:35:22.860 --> 00:35:25.440
<v Gary Greenberg>But that didn't stop people from believing it.

829
00:35:25.820 --> 00:35:27.100
<v Gary Greenberg>And in fact, by then,

830
00:35:27.260 --> 00:35:30.840
<v Gary Greenberg>the myth of the neurochemical imbalance was well underway.

831
00:35:31.120 --> 00:35:33.560
<v Gary Greenberg>It had been promulgated by the Merck company,

832
00:35:33.700 --> 00:35:36.580
<v Gary Greenberg>which had hired a psychiatrist who wrote a book.

833
00:35:36.700 --> 00:35:40.180
<v Gary Greenberg>They put out 50,000 copies to American doctors

834
00:35:40.180 --> 00:35:41.880
<v Gary Greenberg>calling Recognizing the Depressed Patient,

835
00:35:42.140 --> 00:35:45.020
<v Gary Greenberg>in which we see, for the first time,

836
00:35:45.020 --> 00:35:47.020
<v Gary Greenberg>doctors being told to tell their patients

837
00:35:47.020 --> 00:35:49.440
<v Gary Greenberg>that their suffering is a physical problem

838
00:35:49.440 --> 00:35:51.000
<v Gary Greenberg>and that we have the cure for it.

839
00:35:51.080 --> 00:35:53.060
<v Gary Greenberg>Even though they didn't know why it worked.

840
00:35:53.760 --> 00:35:57.580
<v Gary Greenberg>Now, empirical medicine is not a bad thing.

841
00:35:57.960 --> 00:35:59.000
<v Gary Greenberg>You got a migraine?

842
00:35:59.120 --> 00:36:00.660
<v Gary Greenberg>You're getting treated with empirical medicine.

843
00:36:00.960 --> 00:36:03.760
<v Gary Greenberg>Lots of things you're getting treated with are empirical.

844
00:36:04.120 --> 00:36:06.500
<v Gary Greenberg>But that's not where medicine's authority comes from.

845
00:36:06.540 --> 00:36:08.720
<v Gary Greenberg>It's where medicine's authority came from 2,000 years ago.

846
00:36:08.920 --> 00:36:10.780
<v Gary Greenberg>That's how the Hippocratic doctors practiced.

847
00:36:11.160 --> 00:36:12.940
<v Gary Greenberg>Today, we want theories.

848
00:36:13.260 --> 00:36:14.300
<v Gary Greenberg>We want to know.

849
00:36:14.300 --> 00:36:15.120
<v Gary Greenberg>We want to see it.

850
00:36:15.240 --> 00:36:17.980
<v Gary Greenberg>And in the 1960s, they didn't have this.

851
00:36:18.720 --> 00:36:21.220
<v Gary Greenberg>Even in the 1980s, when Prozac came out,

852
00:36:21.320 --> 00:36:22.620
<v Gary Greenberg>they didn't have this.

853
00:36:23.520 --> 00:36:25.800
<v Gary Greenberg>Prozac came out, and all of a sudden,

854
00:36:25.800 --> 00:36:27.540
<v Gary Greenberg>everybody's focus was on serotonin.

855
00:36:27.620 --> 00:36:29.300
<v Gary Greenberg>And everybody has serotonin imbalances

856
00:36:29.820 --> 00:36:31.760
<v Gary Greenberg>or deficiencies or whatever the heck it was,

857
00:36:32.360 --> 00:36:34.600
<v Gary Greenberg>which, by the way, is still told to people today.

858
00:36:35.200 --> 00:36:37.400
<v Gary Greenberg>I'm sure that somewhere today, in this city,

859
00:36:37.500 --> 00:36:38.800
<v Gary Greenberg>some doctor told some patient

860
00:36:38.800 --> 00:36:42.140
<v Gary Greenberg>they needed to take Prozac or whatever

861
00:36:42.140 --> 00:36:44.080
<v Gary Greenberg>because they had a serotonin imbalance.

862
00:36:44.300 --> 00:36:46.420
<v Gary Greenberg>Well, in fact, we don't know what a serotonin balance is.

863
00:36:47.240 --> 00:36:49.460
<v Gary Greenberg>So how the hell do we know what a serotonin imbalance is?

864
00:36:49.520 --> 00:36:52.960
<v Gary Greenberg>We don't know why changing the metabolism of serotonin

865
00:36:52.960 --> 00:36:53.940
<v Gary Greenberg>at the receptor,

866
00:36:54.200 --> 00:36:56.700
<v Gary Greenberg>we don't know why that changes anything.

867
00:36:57.220 --> 00:36:59.360
<v Gary Greenberg>The answer is probably way downstream,

868
00:36:59.620 --> 00:37:04.380
<v Gary Greenberg>buried deep in the hundred trillion synapses in the brain.

869
00:37:05.240 --> 00:37:07.740
<v Gary Greenberg>Somewhere in there in the circuitry, something's getting changed.

870
00:37:07.940 --> 00:37:12.500
<v Gary Greenberg>The serotonin thing, it's just like the finger pointing to the mood.

871
00:37:12.680 --> 00:37:14.200
<v Gary Greenberg>You know, it's not really the...

872
00:37:14.200 --> 00:37:15.400
<v Gary Greenberg>the thing that's happening.

873
00:37:16.340 --> 00:37:16.900
<v Gary Greenberg>And...

874
00:37:16.900 --> 00:37:20.360
<v Gary Greenberg>But this was the salvation.

875
00:37:21.100 --> 00:37:25.200
<v Gary Greenberg>This chemical imbalance theory was the salvation of psychiatry.

876
00:37:25.240 --> 00:37:27.400
<v Gary Greenberg>And then there's one more point that I want to make and then I'll stop.

877
00:37:28.200 --> 00:37:30.220
<v Gary Greenberg>Which is in the 1970s, it took a while

878
00:37:30.220 --> 00:37:33.020
<v Gary Greenberg>between the formation of these neurochemical theories

879
00:37:33.020 --> 00:37:37.180
<v Gary Greenberg>and the real, you know, advent of biological psychiatry.

880
00:37:37.460 --> 00:37:43.140
<v Gary Greenberg>In the 1970s, psychiatry in America ran into very difficult...

881
00:37:43.140 --> 00:37:44.600
<v Gary Greenberg>almost went extinct.

882
00:37:45.140 --> 00:37:48.700
<v Gary Greenberg>The reason was because of the gay agenda.

883
00:37:49.220 --> 00:37:52.900
<v Gary Greenberg>The homosexuals decided that they really didn't want to be mentally ill anymore.

884
00:37:54.040 --> 00:37:58.700
<v Gary Greenberg>And they essentially brought the business of the American Psychiatric Association to a halt.

885
00:38:00.040 --> 00:38:01.000
<v Gary Greenberg>For two years.

886
00:38:01.780 --> 00:38:05.540
<v Gary Greenberg>They protested, they sat in, and finally it took a bunch of gay psychiatrists

887
00:38:05.540 --> 00:38:07.360
<v Gary Greenberg>who had to disguise themselves

888
00:38:08.640 --> 00:38:10.620
<v Gary Greenberg>to talk and say, look, we're gay.

889
00:38:11.600 --> 00:38:12.580
<v Gary Greenberg>We're your brethren.

890
00:38:12.580 --> 00:38:13.680
<v Gary Greenberg>What's going on here?

891
00:38:13.820 --> 00:38:16.580
<v Gary Greenberg>They deleted homosexuality from the manual.

892
00:38:17.340 --> 00:38:18.580
<v Gary Greenberg>There was a couple of other embarrassments.

893
00:38:19.180 --> 00:38:21.320
<v Gary Greenberg>For instance, a...

894
00:38:22.080 --> 00:38:25.000
<v Gary Greenberg>Oh, by the way, that was embarrassing because they didn't do it scientifically.

895
00:38:25.220 --> 00:38:27.100
<v Gary Greenberg>How the hell do you prove something is or isn't a disease

896
00:38:27.100 --> 00:38:28.800
<v Gary Greenberg>if you don't have the biological markers?

897
00:38:28.900 --> 00:38:29.620
<v Gary Greenberg>They did it by vote.

898
00:38:30.100 --> 00:38:31.060
<v Gary Greenberg>It was a referendum.

899
00:38:31.620 --> 00:38:35.160
<v Gary Greenberg>It was the first time that a disease had been eradicated at the stroke of a pen.

900
00:38:37.300 --> 00:38:37.700
<v Gary Greenberg>The...

901
00:38:37.700 --> 00:38:39.800
<v Gary Greenberg>And another thing that happened that I want to mention is that

902
00:38:39.800 --> 00:38:42.560
<v Gary Greenberg>an American professor, David Rosenheim,

903
00:38:42.580 --> 00:38:46.580
<v Gary Greenberg>sent a bunch of students into mental hospitals around the country,

904
00:38:47.320 --> 00:38:48.120
<v Gary Greenberg>checking into...

905
00:38:48.120 --> 00:38:49.420
<v Gary Greenberg>They sent them into the emergency rooms,

906
00:38:49.560 --> 00:38:51.820
<v Gary Greenberg>claiming that they were hearing the word thud in their heads.

907
00:38:52.260 --> 00:38:55.060
<v Gary Greenberg>All of them got admitted as schizophrenic.

908
00:38:55.560 --> 00:38:58.160
<v Gary Greenberg>None of them got released because they weren't...

909
00:38:58.960 --> 00:39:00.880
<v Gary Greenberg>they weren't mentally ill.

910
00:39:01.300 --> 00:39:04.660
<v Gary Greenberg>They got released when they were determined to be schizophrenia in remission.

911
00:39:06.200 --> 00:39:08.320
<v Gary Greenberg>And a couple of them, they had to go in and get them out.

912
00:39:09.020 --> 00:39:11.960
<v Gary Greenberg>And he wrote an article about this in Science Magazine, high profile.

913
00:39:11.960 --> 00:39:14.160
<v Gary Greenberg>It was called, On Being Sane in Insane Places.

914
00:39:14.600 --> 00:39:18.180
<v Gary Greenberg>Now, I think it's perfectly possible to be insane in an insane place.

915
00:39:18.380 --> 00:39:20.660
<v Gary Greenberg>That's how I would describe most crazy people today.

916
00:39:21.040 --> 00:39:24.180
<v Gary Greenberg>But it's also possible to be sane in an insane place,

917
00:39:24.300 --> 00:39:25.460
<v Gary Greenberg>and that's what was going on with them.

918
00:39:25.760 --> 00:39:27.320
<v Gary Greenberg>And the people with the money,

919
00:39:27.960 --> 00:39:28.520
<v Gary Greenberg>the regulators,

920
00:39:28.980 --> 00:39:29.860
<v Gary Greenberg>the government,

921
00:39:30.040 --> 00:39:31.020
<v Gary Greenberg>the universities,

922
00:39:31.140 --> 00:39:32.300
<v Gary Greenberg>they say to the psychiatrists,

923
00:39:32.960 --> 00:39:34.780
<v Gary Greenberg>you guys don't know anything about what you're talking about.

924
00:39:35.040 --> 00:39:38.000
<v Gary Greenberg>What kind of doctor doesn't know the difference between health and illness?

925
00:39:38.580 --> 00:39:41.940
<v Gary Greenberg>What kind of doctor can't name the suffering these treatise?

926
00:39:41.960 --> 00:39:44.420
<v Gary Greenberg>What kind of doctor thinks homosexuality is an illness?

927
00:39:45.300 --> 00:39:47.220
<v Gary Greenberg>And the answer was psychiatrists.

928
00:39:47.360 --> 00:39:52.240
<v Gary Greenberg>And the problem was resolved by creating this diagnostic manual

929
00:39:52.240 --> 00:39:54.540
<v Gary Greenberg>that I spent a couple of years of my life writing about,

930
00:39:54.560 --> 00:39:56.560
<v Gary Greenberg>which I'm totally avoiding talking about because...

931
00:39:56.560 --> 00:39:57.720
<v Gary Greenberg>read the book.

932
00:39:59.960 --> 00:40:04.520
<v Gary Greenberg>But the genius of the DSM is that it says,

933
00:40:04.640 --> 00:40:05.320
<v Gary Greenberg>okay, we don't know.

934
00:40:05.420 --> 00:40:07.160
<v Gary Greenberg>We don't have any of this biological stuff.

935
00:40:07.200 --> 00:40:08.460
<v Gary Greenberg>We're going to go with pure description.

936
00:40:09.460 --> 00:40:10.840
<v Gary Greenberg>And by 1980,

937
00:40:10.840 --> 00:40:13.980
<v Gary Greenberg>the DSM had grown from being a 100-page long book

938
00:40:13.980 --> 00:40:15.080
<v Gary Greenberg>to being a 500-page.

939
00:40:15.260 --> 00:40:18.820
<v Gary Greenberg>It's now 1,000 pages with hundreds of diagnoses,

940
00:40:19.120 --> 00:40:22.540
<v Gary Greenberg>all of which are made purely on the basis of observation.

941
00:40:23.240 --> 00:40:24.360
<v Gary Greenberg>And as I said earlier,

942
00:40:24.440 --> 00:40:28.060
<v Gary Greenberg>there's all these wonderful little codicils and so on

943
00:40:28.060 --> 00:40:32.580
<v Gary Greenberg>that allow doctors to sort of massage things as they need to.

944
00:40:33.540 --> 00:40:35.420
<v Gary Greenberg>Now, you put all of this together,

945
00:40:35.540 --> 00:40:38.940
<v Gary Greenberg>you get this presumably biological psychiatry,

946
00:40:39.000 --> 00:40:40.820
<v Gary Greenberg>this ability to think,

947
00:40:40.840 --> 00:40:43.600
<v Gary Greenberg>to diagnose and create diagnoses for everything.

948
00:40:43.880 --> 00:40:45.080
<v Gary Greenberg>And by the way, that was on purpose.

949
00:40:45.980 --> 00:40:47.940
<v Gary Greenberg>When they went to do the new DSM,

950
00:40:48.120 --> 00:40:49.580
<v Gary Greenberg>the psychoanalysts were worried.

951
00:40:49.700 --> 00:40:50.400
<v Gary Greenberg>They said, well, wait, wait,

952
00:40:50.440 --> 00:40:51.640
<v Gary Greenberg>you're going to take away our bread and butter

953
00:40:51.640 --> 00:40:53.300
<v Gary Greenberg>because we're not really treating mentally ill people.

954
00:40:53.540 --> 00:40:54.680
<v Gary Greenberg>We're treating neurotics.

955
00:40:54.940 --> 00:40:57.680
<v Gary Greenberg>Okay, we'll figure out a way to get all those neuroses in there

956
00:40:57.680 --> 00:40:58.860
<v Gary Greenberg>without ever using the word.

957
00:40:59.360 --> 00:41:01.720
<v Gary Greenberg>So they created all of these different diagnoses

958
00:41:01.720 --> 00:41:04.800
<v Gary Greenberg>that in earlier days were just known as a neurosis,

959
00:41:04.980 --> 00:41:06.680
<v Gary Greenberg>a depressive neurosis.

960
00:41:08.100 --> 00:41:10.380
<v Gary Greenberg>So they had the...

961
00:41:10.380 --> 00:41:10.820
<v Gary Greenberg>they had the...

962
00:41:10.820 --> 00:41:13.220
<v Gary Greenberg>the diagnostic manual that allows them,

963
00:41:14.040 --> 00:41:16.020
<v Gary Greenberg>psychiatry, to reestablish their authority.

964
00:41:16.320 --> 00:41:18.860
<v Gary Greenberg>They have these drugs with the rhetoric about these drugs

965
00:41:18.860 --> 00:41:20.560
<v Gary Greenberg>to make it sound scientific.

966
00:41:21.320 --> 00:41:24.100
<v Gary Greenberg>And then, of course, they have the very willing drug companies,

967
00:41:24.240 --> 00:41:27.040
<v Gary Greenberg>which... for whom these are all markets.

968
00:41:27.320 --> 00:41:29.320
<v Gary Greenberg>And the next thing you know, you have today.

969
00:41:30.080 --> 00:41:32.540
<v Gary Greenberg>You have a time when, in the United States anyway,

970
00:41:33.120 --> 00:41:34.960
<v Gary Greenberg>not only is one in nine people,

971
00:41:35.100 --> 00:41:37.720
<v Gary Greenberg>one in 11 people on antidepressants,

972
00:41:37.720 --> 00:41:38.580
<v Gary Greenberg>but one in 20.

973
00:41:40.200 --> 00:41:40.660
<v Gary Greenberg>Children.

974
00:41:42.520 --> 00:41:45.060
<v Gary Greenberg>And not only that, but...

975
00:41:45.060 --> 00:41:46.780
<v Gary Greenberg>I'm sorry, five in 20 children.

976
00:41:47.160 --> 00:41:47.920
<v Gary Greenberg>Five in 20.

977
00:41:48.000 --> 00:41:51.540
<v Gary Greenberg>One in four children are on psychiatric drugs

978
00:41:51.540 --> 00:41:52.540
<v Gary Greenberg>of some kind or other.

979
00:41:53.180 --> 00:41:55.600
<v Gary Greenberg>And added to that, what we have,

980
00:41:55.740 --> 00:41:57.260
<v Gary Greenberg>is a burgeoning of diagnosis.

981
00:41:57.760 --> 00:42:01.480
<v Gary Greenberg>30% of the American population will qualify for a DSM disorder

982
00:42:01.480 --> 00:42:02.880
<v Gary Greenberg>in any given year.

983
00:42:03.000 --> 00:42:04.440
<v Gary Greenberg>And 50% in their lifetime.

984
00:42:04.840 --> 00:42:06.860
<v Gary Greenberg>When patients come in to me and I say,

985
00:42:06.920 --> 00:42:08.240
<v Gary Greenberg>well, you know, if you want to use your insurance,

986
00:42:08.340 --> 00:42:09.320
<v Gary Greenberg>which I really discourage,

987
00:42:09.780 --> 00:42:10.580
<v Gary Greenberg>I have to...

988
00:42:10.580 --> 00:42:10.640
<v Gary Greenberg>I have to...

989
00:42:10.640 --> 00:42:12.760
<v Gary Greenberg>We have to decide what mental illness you have.

990
00:42:13.260 --> 00:42:14.480
<v Gary Greenberg>They look at me like, what?

991
00:42:15.060 --> 00:42:17.360
<v Gary Greenberg>Yeah, you have to have a mental illness to get this paper.

992
00:42:17.440 --> 00:42:18.720
<v Gary Greenberg>Well, fortunately, there's a book full of them.

993
00:42:18.760 --> 00:42:20.160
<v Gary Greenberg>We take it down, we find one that works.

994
00:42:21.940 --> 00:42:25.500
<v Gary Greenberg>So I want to go back to the example of childhood bipolar

995
00:42:25.500 --> 00:42:27.540
<v Gary Greenberg>because I want to tell you what happened to it.

996
00:42:27.620 --> 00:42:29.160
<v Gary Greenberg>This is one part of the DSM.

997
00:42:29.220 --> 00:42:31.420
<v Gary Greenberg>And this will sort of bring this together, I hope,

998
00:42:31.500 --> 00:42:33.240
<v Gary Greenberg>in some way that you can leave with something.

999
00:42:34.600 --> 00:42:35.940
<v Gary Greenberg>This was a huge scandal.

1000
00:42:36.740 --> 00:42:38.600
<v Gary Greenberg>It was scandalous because it happened.

1001
00:42:38.640 --> 00:42:40.100
<v Gary Greenberg>And it was scandalous because nothing happened.

1002
00:42:40.640 --> 00:42:41.360
<v Gary Greenberg>Nothing changed.

1003
00:42:41.840 --> 00:42:43.440
<v Gary Greenberg>These kids are still getting these drugs.

1004
00:42:43.800 --> 00:42:45.000
<v Gary Greenberg>Biederman is still at Harvard.

1005
00:42:45.680 --> 00:42:47.960
<v Gary Greenberg>I had to go through some kind of huge legal scrutiny

1006
00:42:47.960 --> 00:42:49.460
<v Gary Greenberg>just to write this in a book

1007
00:42:49.460 --> 00:42:50.940
<v Gary Greenberg>because they were afraid we'd get sued for libel.

1008
00:42:51.540 --> 00:42:53.380
<v Gary Greenberg>And that was in the United States, not even in England,

1009
00:42:53.420 --> 00:42:55.760
<v Gary Greenberg>where you can get sued for libel for looking at somebody the wrong way.

1010
00:42:57.460 --> 00:42:59.280
<v Gary Greenberg>What did they decide to do about it?

1011
00:42:59.620 --> 00:43:02.300
<v Gary Greenberg>The American Psychiatric Association, which owns the DSM...

1012
00:43:02.300 --> 00:43:05.240
<v Gary Greenberg>And by the way, I apologize for all the stuff we export to you all.

1013
00:43:05.720 --> 00:43:08.020
<v Gary Greenberg>You know, I think American foreign policy should consist of

1014
00:43:08.020 --> 00:43:10.060
<v Gary Greenberg>protecting the rest of the world from us.

1015
00:43:10.720 --> 00:43:13.720
<v Gary Greenberg>And in the case of the DSM, we've done a terrible job.

1016
00:43:15.060 --> 00:43:17.960
<v Gary Greenberg>What they decided to do, they were faced with a choice.

1017
00:43:18.160 --> 00:43:21.060
<v Gary Greenberg>They could put a black box warning right in the diagnosis.

1018
00:43:21.580 --> 00:43:23.720
<v Gary Greenberg>Don't diagnose children with this disorder.

1019
00:43:24.440 --> 00:43:25.420
<v Gary Greenberg>It is forbidden.

1020
00:43:25.820 --> 00:43:27.740
<v Gary Greenberg>None of this trump card shit, right?

1021
00:43:27.920 --> 00:43:29.960
<v Gary Greenberg>Just do it or don't do it.

1022
00:43:30.100 --> 00:43:31.140
<v Gary Greenberg>They could have done that.

1023
00:43:31.580 --> 00:43:34.880
<v Gary Greenberg>But instead what they did was they created a new diagnosis.

1024
00:43:35.380 --> 00:43:38.520
<v Gary Greenberg>It's called disruptive mood dysregulation disorder.

1025
00:43:39.560 --> 00:43:42.620
<v Gary Greenberg>And it used to be called temper dysregulation disorder,

1026
00:43:42.880 --> 00:43:45.100
<v Gary Greenberg>but the word temper really upset the focus groups.

1027
00:43:45.200 --> 00:43:46.820
<v Gary Greenberg>And if you think I'm kidding, read my book.

1028
00:43:47.080 --> 00:43:48.820
<v Gary Greenberg>And they changed the name.

1029
00:43:48.900 --> 00:43:50.020
<v Gary Greenberg>They didn't change anything else.

1030
00:43:50.480 --> 00:43:54.040
<v Gary Greenberg>And disruptive mood dysregulation disorder does very nicely describe these kids,

1031
00:43:54.120 --> 00:43:55.980
<v Gary Greenberg>but it's still not different from ODD.

1032
00:43:56.320 --> 00:43:58.740
<v Gary Greenberg>It's still about the reputation of the diagnosis.

1033
00:43:59.520 --> 00:44:02.660
<v Gary Greenberg>And the stated reason for this, it's never, you know,

1034
00:44:02.660 --> 00:44:05.140
<v Gary Greenberg>they're never going to explicitly say it's about the drugs

1035
00:44:05.140 --> 00:44:06.760
<v Gary Greenberg>because the DSM is not a treatment manual.

1036
00:44:06.920 --> 00:44:08.500
<v Gary Greenberg>The explicit reason is because it's not a treatment manual.

1037
00:44:08.520 --> 00:44:09.980
<v Gary Greenberg>It's because these kids need a diagnostic home.

1038
00:44:10.180 --> 00:44:14.800
<v Gary Greenberg>As if they were, you know, urchins and they'd been expelled from Fagan's orphanage

1039
00:44:14.800 --> 00:44:16.840
<v Gary Greenberg>and they need to find a better orphanage.

1040
00:44:17.020 --> 00:44:26.060
<v Gary Greenberg>The DMDD diagnosis is already under trials for drugs.

1041
00:44:26.320 --> 00:44:30.100
<v Gary Greenberg>There's nothing to stop it from turning into yet another disorder that's diagnosed.

1042
00:44:30.280 --> 00:44:30.480
<v Gary Greenberg>Why?

1043
00:44:30.800 --> 00:44:34.380
<v Gary Greenberg>Because parents are desperate when they have children like this.

1044
00:44:34.860 --> 00:44:37.980
<v Gary Greenberg>And because we're much better at pathologizing individuals

1045
00:44:38.680 --> 00:44:40.600
<v Gary Greenberg>and turning their troubles into markets

1046
00:44:40.600 --> 00:44:44.300
<v Gary Greenberg>than we are at looking at these very comprehensive problems.

1047
00:44:47.480 --> 00:44:51.060
<v Gary Greenberg>Inventing DMDD to solve the childhood bipolar problem

1048
00:44:51.060 --> 00:44:53.280
<v Gary Greenberg>is like swallowing a spider to kill a fly.

1049
00:44:54.100 --> 00:44:57.240
<v Gary Greenberg>You know, what do they swallow after? A spider? A bird?

1050
00:44:57.400 --> 00:44:59.340
<v Gary Greenberg>I mean, it just, you know, keeps going on and on.

1051
00:45:00.200 --> 00:45:03.580
<v Gary Greenberg>They made a similar change, I just want to point this one out,

1052
00:45:03.640 --> 00:45:08.040
<v Gary Greenberg>to the depression diagnosis to allow doctors to diagnose people with depression.

1053
00:45:09.440 --> 00:45:12.540
<v Gary Greenberg>Even if they're only within a couple of weeks of being bereaved.

1054
00:45:14.020 --> 00:45:18.920
<v Gary Greenberg>So if you lose your loved one and you go to your doctor and you're really upset,

1055
00:45:20.480 --> 00:45:22.200
<v Gary Greenberg>you can be diagnosed with a mental illness.

1056
00:45:22.900 --> 00:45:27.980
<v Gary Greenberg>Now this gets to the question that we started with about stigma.

1057
00:45:28.420 --> 00:45:30.500
<v Gary Greenberg>Did we start with that or was that just between you and me?

1058
00:45:30.940 --> 00:45:32.000
<v Gary Greenberg>Did you say stigma?

1059
00:45:32.340 --> 00:45:33.960
<v Gary Greenberg>We mentioned it. Okay, so good.

1060
00:45:34.580 --> 00:45:36.320
<v Gary Greenberg>My memory is not what it used to be.

1061
00:45:36.320 --> 00:45:40.460
<v Gary Greenberg>So what happens when somebody tells you you're mentally ill?

1062
00:45:40.540 --> 00:45:43.720
<v Gary Greenberg>Well, once you get over your objection, you know, the DSM is like a book of insults.

1063
00:45:43.960 --> 00:45:49.500
<v Gary Greenberg>Once you get over your objections to being diagnosed that way,

1064
00:45:49.620 --> 00:45:51.020
<v Gary Greenberg>then you start to think of yourself,

1065
00:45:51.500 --> 00:45:53.420
<v Gary Greenberg>well, wait a minute, maybe I am mentally ill.

1066
00:45:53.880 --> 00:45:57.060
<v Gary Greenberg>Maybe the reason that I can't, I'm so torn up with grief.

1067
00:45:57.400 --> 00:46:01.120
<v Gary Greenberg>Peter Carey, the Australian novelist, just wrote a tremendous book called

1068
00:46:01.120 --> 00:46:05.480
<v Gary Greenberg>The Chemistry of Tears in which he writes about obsessive grief in a way that,

1069
00:46:05.480 --> 00:46:07.920
<v Gary Greenberg>I mean, if you come away from that feeling like the lady is sick,

1070
00:46:08.560 --> 00:46:09.440
<v Gary Greenberg>you're a psychiatrist.

1071
00:46:12.680 --> 00:46:18.480
<v Gary Greenberg>The idea that you're suffering, your grief is illness, works on you like a worm.

1072
00:46:18.680 --> 00:46:19.360
<v Gary Greenberg>I've had this happen.

1073
00:46:19.600 --> 00:46:22.300
<v Gary Greenberg>I participated in a clinical trial to write about it.

1074
00:46:22.600 --> 00:46:26.220
<v Gary Greenberg>I was diagnosed with major depression, which was completely wrong, but whatever.

1075
00:46:26.580 --> 00:46:28.680
<v Gary Greenberg>I went in to get a minor depression diagnosis.

1076
00:46:28.800 --> 00:46:31.160
<v Gary Greenberg>It was the Bush years. Everybody was minorly depressed.

1077
00:46:31.720 --> 00:46:33.480
<v Gary Greenberg>They told me I had major depression.

1078
00:46:34.640 --> 00:46:35.460
<v Gary Greenberg>And what I did was I went in and I was diagnosed with depression.

1079
00:46:35.480 --> 00:46:38.320
<v Gary Greenberg>The weird thing was that over the ten weeks of the trial,

1080
00:46:38.460 --> 00:46:41.440
<v Gary Greenberg>I kept thinking, you know, maybe I am sick.

1081
00:46:42.180 --> 00:46:45.340
<v Gary Greenberg>Maybe my temperament is not my temperament.

1082
00:46:45.380 --> 00:46:46.680
<v Gary Greenberg>Maybe I've got a chemical imbalance.

1083
00:46:46.960 --> 00:46:50.160
<v Gary Greenberg>It was very strange that I, of all people, would be thinking of this.

1084
00:46:50.320 --> 00:46:54.260
<v Gary Greenberg>So the issue there is that it changes the way people understand something

1085
00:46:54.260 --> 00:46:57.400
<v Gary Greenberg>really important about themselves and their lives.

1086
00:46:57.520 --> 00:46:59.700
<v Gary Greenberg>And by the way, nothing in there is about drugs.

1087
00:47:00.000 --> 00:47:03.160
<v Gary Greenberg>You go to your doctor, your doctor wants to give you psychiatric drugs.

1088
00:47:03.340 --> 00:47:04.180
<v Gary Greenberg>He could do that.

1089
00:47:04.180 --> 00:47:05.720
<v Gary Greenberg>Or she could do that without a diagnosis.

1090
00:47:06.220 --> 00:47:09.500
<v Gary Greenberg>Three quarters of the psychiatric drugs prescribed in the United States

1091
00:47:09.500 --> 00:47:11.480
<v Gary Greenberg>are prescribed in the absence of a diagnosis.

1092
00:47:12.120 --> 00:47:16.620
<v Gary Greenberg>What the diagnoses do isn't tell you what drugs to use.

1093
00:47:16.780 --> 00:47:20.720
<v Gary Greenberg>It's what establishes the authority of psychiatry that lets people believe

1094
00:47:20.720 --> 00:47:23.920
<v Gary Greenberg>that it's a good idea to take psychiatric drugs in the first place.

1095
00:47:25.940 --> 00:47:29.960
<v Gary Greenberg>So I just want to end by telling you something that is sort of hopeful

1096
00:47:29.960 --> 00:47:34.160
<v Gary Greenberg>but sort of weird, which is the marketplace is decidedly

1097
00:47:34.160 --> 00:47:39.300
<v Gary Greenberg>right now as we speak that this whole idea about chemical imbalances

1098
00:47:39.300 --> 00:47:42.740
<v Gary Greenberg>and psychiatric drugs is a bad idea.

1099
00:47:43.220 --> 00:47:47.160
<v Gary Greenberg>And the way we know that is that all of the major pharmaceutical companies

1100
00:47:47.720 --> 00:47:49.960
<v Gary Greenberg>have pulled out of the psychiatric drug business.

1101
00:47:50.560 --> 00:47:52.780
<v Gary Greenberg>They still make the stuff we know about.

1102
00:47:52.960 --> 00:47:53.440
<v Gary Greenberg>Don't worry.

1103
00:47:53.680 --> 00:47:55.120
<v Gary Greenberg>You'll still be able to get it.

1104
00:47:55.240 --> 00:47:57.640
<v Gary Greenberg>But there's no new drugs in the pipeline.

1105
00:47:58.000 --> 00:47:59.060
<v Gary Greenberg>They've shut down.

1106
00:47:59.640 --> 00:48:00.980
<v Gary Greenberg>And I don't mean all of them.

1107
00:48:01.520 --> 00:48:02.040
<v Gary Greenberg>Why?

1108
00:48:02.800 --> 00:48:04.140
<v Gary Greenberg>Because they know it's a myth.

1109
00:48:04.140 --> 00:48:06.520
<v Gary Greenberg>They know there's no chemical imbalance.

1110
00:48:06.860 --> 00:48:09.500
<v Gary Greenberg>And they know that we don't know what diseases we're treating.

1111
00:48:10.220 --> 00:48:12.000
<v Gary Greenberg>So they said, well, why should we do that?

1112
00:48:12.080 --> 00:48:13.760
<v Gary Greenberg>We're wasting hundreds of millions of dollars

1113
00:48:13.760 --> 00:48:15.900
<v Gary Greenberg>with mythical chemical imbalances

1114
00:48:16.920 --> 00:48:19.560
<v Gary Greenberg>researching on diseases that everybody knows don't exist.

1115
00:48:19.880 --> 00:48:23.220
<v Gary Greenberg>Because, by the way, there's no psychiatrist, DSM or anti-DSM,

1116
00:48:23.240 --> 00:48:25.740
<v Gary Greenberg>who will tell you that these disorders really exist.

1117
00:48:26.040 --> 00:48:27.900
<v Gary Greenberg>They're moving out of the business.

1118
00:48:29.020 --> 00:48:32.420
<v Gary Greenberg>So what might happen, you know, maybe not in my lifetime,

1119
00:48:32.660 --> 00:48:34.120
<v Gary Greenberg>is that this idea that crazy drugs exist

1120
00:48:34.140 --> 00:48:36.260
<v Gary Greenberg>and that craziness is sickness might be rethought.

1121
00:48:37.080 --> 00:48:39.000
<v Gary Greenberg>I don't know what craziness is either.

1122
00:48:39.300 --> 00:48:41.280
<v Gary Greenberg>I can't tell you that I have a better idea.

1123
00:48:41.500 --> 00:48:43.500
<v Gary Greenberg>I just know that this idea that it's sickness

1124
00:48:44.140 --> 00:48:45.860
<v Gary Greenberg>has brought us a lot of trouble.

1125
00:48:46.080 --> 00:48:48.360
<v Gary Greenberg>And it's in the absence of any proof.

1126
00:48:48.660 --> 00:48:49.820
<v Gary Greenberg>The jury's still out.

1127
00:48:50.180 --> 00:48:52.100
<v Gary Greenberg>And like I say, the market seems to be voting

1128
00:48:53.200 --> 00:48:55.700
<v Gary Greenberg>that this wasn't such a good idea to begin with.

1129
00:48:55.740 --> 00:48:56.720
<v Gary Greenberg>There's a wonderful thing about markets.

1130
00:48:57.160 --> 00:49:00.080
<v Gary Greenberg>Markets are what put nuclear power plants out of business in the United States.

1131
00:49:00.360 --> 00:49:02.220
<v Gary Greenberg>You know, it wasn't that they were a bad idea.

1132
00:49:02.300 --> 00:49:03.220
<v Gary Greenberg>It was they didn't pay.

1133
00:49:04.420 --> 00:49:07.020
<v Gary Greenberg>And the last weird thing I want to say

1134
00:49:07.020 --> 00:49:09.880
<v Gary Greenberg>is that we have to bear in mind

1135
00:49:09.880 --> 00:49:11.640
<v Gary Greenberg>that the big problem with psychiatry,

1136
00:49:11.700 --> 00:49:14.080
<v Gary Greenberg>the one about not having diseases to treat,

1137
00:49:15.000 --> 00:49:17.200
<v Gary Greenberg>that's actually a problem in all of medicine.

1138
00:49:17.580 --> 00:49:21.080
<v Gary Greenberg>This magic bullet model worked real well

1139
00:49:21.080 --> 00:49:25.500
<v Gary Greenberg>for infection, for conditions like diabetes,

1140
00:49:25.660 --> 00:49:27.540
<v Gary Greenberg>for certain metabolic diseases and so on.

1141
00:49:28.060 --> 00:49:30.540
<v Gary Greenberg>But the low-hanging fruit has been picked.

1142
00:49:31.400 --> 00:49:33.660
<v Gary Greenberg>And when we look at the advent of,

1143
00:49:33.660 --> 00:49:35.980
<v Gary Greenberg>of anti-inflammatory, I'm sorry,

1144
00:49:36.120 --> 00:49:40.220
<v Gary Greenberg>anti-immune, anti-immune disorders,

1145
00:49:40.860 --> 00:49:42.180
<v Gary Greenberg>autoimmune disorders, I'm sorry,

1146
00:49:42.300 --> 00:49:45.000
<v Gary Greenberg>autoimmune disorders and inflammatory disorders

1147
00:49:45.000 --> 00:49:46.980
<v Gary Greenberg>and cancers and other diseases

1148
00:49:46.980 --> 00:49:49.080
<v Gary Greenberg>that don't yield to this model,

1149
00:49:49.300 --> 00:49:50.660
<v Gary Greenberg>what we might be seeing,

1150
00:49:50.860 --> 00:49:52.760
<v Gary Greenberg>and my psychiatrist friends in the audience

1151
00:49:52.760 --> 00:49:54.160
<v Gary Greenberg>will be pleased to hear me say this,

1152
00:49:54.280 --> 00:49:57.040
<v Gary Greenberg>is that psychiatry may not be lagging behind at all.

1153
00:49:57.920 --> 00:49:59.680
<v Gary Greenberg>Psychiatry may be out on the leading edge,

1154
00:50:00.400 --> 00:50:03.140
<v Gary Greenberg>trying to figure out what's wrong with us,

1155
00:50:03.140 --> 00:50:05.580
<v Gary Greenberg>without reducing it to biology.

1156
00:50:06.200 --> 00:50:08.500
<v Gary Greenberg>Because while biology is obviously important,

1157
00:50:08.680 --> 00:50:10.160
<v Gary Greenberg>obviously the necessary condition,

1158
00:50:10.400 --> 00:50:11.640
<v Gary Greenberg>whether it's the biology of the brain

1159
00:50:11.640 --> 00:50:13.160
<v Gary Greenberg>or the biology of the gut,

1160
00:50:13.260 --> 00:50:14.280
<v Gary Greenberg>and by the way, they have a lot in common,

1161
00:50:14.320 --> 00:50:15.780
<v Gary Greenberg>there's a lot of serotonin in your gut too,

1162
00:50:16.560 --> 00:50:18.760
<v Gary Greenberg>whether it's one or the other,

1163
00:50:18.820 --> 00:50:21.480
<v Gary Greenberg>the biology is the necessary condition,

1164
00:50:21.700 --> 00:50:24.820
<v Gary Greenberg>but we don't know what the sufficient conditions are.

1165
00:50:25.720 --> 00:50:29.140
<v Gary Greenberg>Suffering remains an enormous mystery.

1166
00:50:29.540 --> 00:50:31.280
<v Gary Greenberg>I personally, at this point,

1167
00:50:31.320 --> 00:50:33.120
<v Gary Greenberg>having suffered for 56 years,

1168
00:50:33.140 --> 00:50:34.600
<v Gary Greenberg>I'm resigned to it.

1169
00:50:35.720 --> 00:50:38.100
<v Gary Greenberg>That suffering is going to continue to be a mystery,

1170
00:50:38.280 --> 00:50:40.860
<v Gary Greenberg>and I'm not sure we should work so hard,

1171
00:50:40.920 --> 00:50:43.080
<v Gary Greenberg>quite so hard, to take it away.

1172
00:50:44.040 --> 00:50:48.700
<v Gary Greenberg>But I do think that the market, ironically enough,

1173
00:50:48.920 --> 00:50:50.700
<v Gary Greenberg>is what's going to make that possible.

1174
00:50:51.420 --> 00:50:52.460
<v Gary Greenberg>And that's all I have to say.

1175
00:50:52.640 --> 00:50:53.040
<v Robyn Williams>Thank you.

1176
00:51:01.460 --> 00:51:02.980
<v Robyn Williams>Now, is it half past six?

1177
00:51:03.140 --> 00:51:04.420
<v Robyn Williams>No, it isn't. Amazing.

1178
00:51:06.320 --> 00:51:08.940
<v Robyn Williams>I'm going to ask you the question I asked Thomas Satz.

1179
00:51:09.080 --> 00:51:11.280
<v Robyn Williams>If you are a therapist,

1180
00:51:12.560 --> 00:51:13.840
<v Robyn Williams>and I come to see you,

1181
00:51:13.880 --> 00:51:15.040
<v Robyn Williams>somebody comes to see you,

1182
00:51:15.060 --> 00:51:18.260
<v Robyn Williams>and you don't know that there's any scientific basis

1183
00:51:18.260 --> 00:51:19.200
<v Robyn Williams>for what you're about to do,

1184
00:51:19.840 --> 00:51:20.880
<v Robyn Williams>how do you treat them?

1185
00:51:21.760 --> 00:51:23.200
<v Robyn Williams>Well, first of all, you tell them that.

1186
00:51:24.540 --> 00:51:26.520
<v Gary Greenberg>I mean, the first thing you do is you say,

1187
00:51:28.700 --> 00:51:29.700
<v Gary Greenberg>I'm not a scientist.

1188
00:51:30.320 --> 00:51:32.380
<v Gary Greenberg>One way or the other, you have to disabuse people

1189
00:51:32.380 --> 00:51:34.560
<v Gary Greenberg>of the notion that this is a medical treatment.

1190
00:51:34.800 --> 00:51:36.840
<v Robyn Williams>And you have some rationale for what you're going to do next

1191
00:51:36.840 --> 00:51:37.820
<v Robyn Williams>in terms of therapy?

1192
00:51:37.840 --> 00:51:39.700
<v Robyn Williams>Yeah, therapy is a placebo treatment.

1193
00:51:42.060 --> 00:51:43.520
<v Gary Greenberg>But that's not a bad thing.

1194
00:51:43.680 --> 00:51:45.320
<v Gary Greenberg>Some of my best friends are placebos.

1195
00:51:46.640 --> 00:51:48.780
<v Gary Greenberg>It's a placebo treatment in the sense that

1196
00:51:49.380 --> 00:51:52.880
<v Gary Greenberg>placebo is the oldest treatment.

1197
00:51:53.660 --> 00:51:54.420
<v Robyn Williams>Shaman do it.

1198
00:51:54.480 --> 00:51:55.260
<v Robyn Williams>Shaman do it, yeah.

1199
00:51:55.360 --> 00:51:56.460
<v Gary Greenberg>Birds and the bees do it.

1200
00:51:56.660 --> 00:52:02.360
<v Gary Greenberg>The placebo effect simply is saying that there's a...

1201
00:52:02.360 --> 00:52:03.160
<v Gary Greenberg>a healing relationship,

1202
00:52:03.780 --> 00:52:05.340
<v Gary Greenberg>and that people benefit from it.

1203
00:52:05.520 --> 00:52:06.840
<v Gary Greenberg>That if you come to somebody,

1204
00:52:07.020 --> 00:52:09.100
<v Gary Greenberg>it doesn't matter if it's a priest or a shaman or a shrink,

1205
00:52:09.300 --> 00:52:10.920
<v Gary Greenberg>or just your family doc,

1206
00:52:12.540 --> 00:52:14.400
<v Gary Greenberg>that somehow there's benefit in it.

1207
00:52:14.600 --> 00:52:16.480
<v Gary Greenberg>And what psychotherapy is is an attempt,

1208
00:52:16.700 --> 00:52:17.640
<v Gary Greenberg>at least in its best,

1209
00:52:17.760 --> 00:52:19.000
<v Gary Greenberg>and this was Freud's...

1210
00:52:19.000 --> 00:52:20.260
<v Gary Greenberg>I mean, Freud got almost everything wrong,

1211
00:52:20.320 --> 00:52:21.860
<v Gary Greenberg>but he also got almost everything right

1212
00:52:21.860 --> 00:52:23.140
<v Gary Greenberg>because he did understand

1213
00:52:23.740 --> 00:52:26.200
<v Gary Greenberg>that if you make the relationship itself

1214
00:52:26.880 --> 00:52:28.340
<v Gary Greenberg>the focus of the relationship,

1215
00:52:28.540 --> 00:52:30.080
<v Gary Greenberg>which sounds, you know, totally like,

1216
00:52:30.080 --> 00:52:31.980
<v Gary Greenberg>head up your rear end,

1217
00:52:32.360 --> 00:52:32.740
<v Gary Greenberg>circular,

1218
00:52:33.020 --> 00:52:34.160
<v Gary Greenberg>if you do that,

1219
00:52:34.640 --> 00:52:36.280
<v Gary Greenberg>you actually change.

1220
00:52:37.260 --> 00:52:41.080
<v Gary Greenberg>So I think that I tell people this is a placebo treatment.

1221
00:52:42.300 --> 00:52:43.640
<v Robyn Williams>Now, what if I say,

1222
00:52:43.680 --> 00:52:45.280
<v Robyn Williams>look, okay, thank you, doctor,

1223
00:52:45.400 --> 00:52:46.060
<v Robyn Williams>if I call you doctor,

1224
00:52:46.880 --> 00:52:50.080
<v Robyn Williams>and I have some sort of insurance,

1225
00:52:50.540 --> 00:52:52.540
<v Robyn Williams>and I don't want to pay you privately

1226
00:52:52.540 --> 00:52:53.760
<v Robyn Williams>because I can't afford it.

1227
00:52:55.280 --> 00:52:58.100
<v Robyn Williams>Will you give me a diagnosis with a disease

1228
00:52:58.100 --> 00:52:59.340
<v Robyn Williams>so that I can get my money back?

1229
00:52:59.460 --> 00:53:01.240
<v Gary Greenberg>I will, but first I'm going to make sure

1230
00:53:01.240 --> 00:53:02.180
<v Gary Greenberg>you really can't afford it.

1231
00:53:02.780 --> 00:53:04.020
<v Gary Greenberg>And I'm going to ask you

1232
00:53:04.020 --> 00:53:05.420
<v Gary Greenberg>what you spend your money on.

1233
00:53:05.880 --> 00:53:07.220
<v Gary Greenberg>And I'm going to say to you,

1234
00:53:07.300 --> 00:53:09.060
<v Gary Greenberg>do you really think that it's fair to you

1235
00:53:09.060 --> 00:53:12.620
<v Gary Greenberg>spend social resources on this treatment?

1236
00:53:13.720 --> 00:53:14.780
<v Gary Greenberg>And I'm going to say,

1237
00:53:14.920 --> 00:53:16.260
<v Gary Greenberg>and at the expense, by the way,

1238
00:53:16.280 --> 00:53:17.500
<v Gary Greenberg>now I'll appeal to your self-interest,

1239
00:53:17.760 --> 00:53:19.700
<v Gary Greenberg>you know, this goes on your permanent medical record,

1240
00:53:19.880 --> 00:53:21.300
<v Gary Greenberg>if you ever want to run for president,

1241
00:53:21.400 --> 00:53:22.060
<v Gary Greenberg>which you can't do

1242
00:53:22.640 --> 00:53:24.280
<v Gary Greenberg>because you're not from our country,

1243
00:53:25.760 --> 00:53:27.100
<v Gary Greenberg>it might come to light

1244
00:53:27.100 --> 00:53:28.800
<v Gary Greenberg>if you ever want to get life insurance.

1245
00:53:28.940 --> 00:53:31.080
<v Gary Greenberg>So I'll do my best to talk you out of it.

1246
00:53:31.240 --> 00:53:32.800
<v Gary Greenberg>But if I fail,

1247
00:53:33.260 --> 00:53:35.680
<v Gary Greenberg>and you still don't think I'm too much of a jerk

1248
00:53:36.240 --> 00:53:36.680
<v Gary Greenberg>for trying,

1249
00:53:36.860 --> 00:53:39.380
<v Gary Greenberg>then what I'll do is I will say,

1250
00:53:39.500 --> 00:53:40.900
<v Gary Greenberg>well, here's the mental,

1251
00:53:40.980 --> 00:53:42.380
<v Gary Greenberg>either here's the mental illness

1252
00:53:42.380 --> 00:53:43.580
<v Gary Greenberg>you actually qualify for,

1253
00:53:44.460 --> 00:53:46.640
<v Gary Greenberg>or here's a couple that you could qualify for,

1254
00:53:46.740 --> 00:53:47.800
<v Gary Greenberg>which one do you want?

1255
00:53:49.400 --> 00:53:50.000
<v Robyn Williams>I see.

1256
00:53:50.560 --> 00:53:51.840
<v Robyn Williams>It's democratic like that.

1257
00:53:51.900 --> 00:53:52.820
<v Gary Greenberg>Yeah, well, it has to be, right?

1258
00:53:52.860 --> 00:53:55.360
<v Gary Greenberg>Because everybody, look, everybody knows,

1259
00:53:55.480 --> 00:53:56.640
<v Gary Greenberg>everybody in my industry,

1260
00:53:57.160 --> 00:53:58.040
<v Gary Greenberg>psychiatrists, therapists,

1261
00:53:58.260 --> 00:54:00.820
<v Gary Greenberg>everybody knows that it's a farce.

1262
00:54:01.480 --> 00:54:03.420
<v Gary Greenberg>It's the most cynical book in the world.

1263
00:54:03.560 --> 00:54:06.420
<v Gary Greenberg>It's like the attitude of psychiatrists or DSM,

1264
00:54:06.500 --> 00:54:08.880
<v Gary Greenberg>it's like if you could imagine the priest at the Vatican

1265
00:54:09.220 --> 00:54:10.280
<v Gary Greenberg>thinking about the new pope

1266
00:54:10.280 --> 00:54:11.240
<v Gary Greenberg>and sitting around and talking about

1267
00:54:11.240 --> 00:54:13.580
<v Gary Greenberg>what a crock of shit the book of Revelations is.

1268
00:54:14.040 --> 00:54:16.480
<v Gary Greenberg>I mean, it's like that's what it's like in my industry.

1269
00:54:17.640 --> 00:54:20.100
<v Gary Greenberg>So instead of starting off with a lie

1270
00:54:21.080 --> 00:54:24.560
<v Gary Greenberg>in a relationship that's supposed to be about the truth,

1271
00:54:24.680 --> 00:54:26.040
<v Gary Greenberg>you just get it out there on the table.

1272
00:54:26.180 --> 00:54:26.380
<v Robyn Williams>Sure.

1273
00:54:26.880 --> 00:54:28.060
<v Robyn Williams>I'm going to ask you a final question,

1274
00:54:28.200 --> 00:54:30.080
<v Robyn Williams>well, two questions rolled into one,

1275
00:54:30.100 --> 00:54:31.140
<v Robyn Williams>so that you can have a chance.

1276
00:54:32.120 --> 00:54:34.760
<v Robyn Williams>The first, it's really about the way that,

1277
00:54:34.780 --> 00:54:36.460
<v Robyn Williams>even if you don't know the biology,

1278
00:54:36.680 --> 00:54:37.920
<v Robyn Williams>the drugs seem to work.

1279
00:54:38.120 --> 00:54:39.660
<v Robyn Williams>I had a friend who's now dead

1280
00:54:39.660 --> 00:54:42.940
<v Robyn Williams>called Stuart Sutherland at the University of Sussex,

1281
00:54:43.620 --> 00:54:46.020
<v Robyn Williams>professor of psychology, mind you,

1282
00:54:46.060 --> 00:54:47.700
<v Robyn Williams>dealt with the biology of perception,

1283
00:54:47.960 --> 00:54:49.440
<v Robyn Williams>but you know, he a general psychologist,

1284
00:54:49.580 --> 00:54:51.200
<v Robyn Williams>and he broke down.

1285
00:54:51.340 --> 00:54:53.140
<v Robyn Williams>He was a manic depressive

1286
00:54:53.700 --> 00:54:55.140
<v Robyn Williams>and he wrote a book called Breakdown.

1287
00:54:55.960 --> 00:54:58.620
<v Robyn Williams>And once when I went to see him at the University of Sussex,

1288
00:54:58.680 --> 00:55:00.840
<v Robyn Williams>he had this huge bottle, gin,

1289
00:55:02.120 --> 00:55:03.520
<v Robyn Williams>in fact it was water,

1290
00:55:04.460 --> 00:55:05.980
<v Robyn Williams>because we were about to go out to dinner

1291
00:55:05.980 --> 00:55:06.340
<v Robyn Williams>and he was going,

1292
00:55:06.380 --> 00:55:09.120
<v Robyn Williams>and I said,

1293
00:55:09.220 --> 00:55:10.900
<v Robyn Williams>are you sure you're going to make it to dinner?

1294
00:55:11.720 --> 00:55:14.060
<v Robyn Williams>And he said he just put it in a gin bottle

1295
00:55:14.060 --> 00:55:15.080
<v Robyn Williams>to shock his students,

1296
00:55:15.920 --> 00:55:17.040
<v Robyn Williams>because it was on lithium,

1297
00:55:18.000 --> 00:55:20.460
<v Robyn Williams>which of course has an Australian origin in many ways,

1298
00:55:20.480 --> 00:55:22.300
<v Robyn Williams>it's a therapeutic drug.

1299
00:55:22.660 --> 00:55:24.340
<v Robyn Williams>And he liked to shock his students,

1300
00:55:24.480 --> 00:55:26.360
<v Robyn Williams>but the lithium worked.

1301
00:55:26.700 --> 00:55:27.640
<v Robyn Williams>But the strange thing was,

1302
00:55:27.660 --> 00:55:28.880
<v Robyn Williams>it wasn't popular with drug companies

1303
00:55:28.880 --> 00:55:29.740
<v Robyn Williams>because it was so cheap.

1304
00:55:30.340 --> 00:55:32.980
<v Robyn Williams>You couldn't necessarily make an industry out of it.

1305
00:55:33.060 --> 00:55:35.720
<v Robyn Williams>But the second example is rather close to home.

1306
00:55:35.780 --> 00:55:40.400
<v Robyn Williams>My daughter's supervisor when she was doing an MA

1307
00:55:40.400 --> 00:55:41.360
<v Robyn Williams>at the University of Sydney,

1308
00:55:41.400 --> 00:55:42.160
<v Robyn Williams>was Nick Waterlow,

1309
00:55:42.360 --> 00:55:44.800
<v Robyn Williams>a very famous arts person,

1310
00:55:45.100 --> 00:55:49.180
<v Robyn Williams>whose son was off his psychotic remedies,

1311
00:55:50.700 --> 00:55:52.600
<v Robyn Williams>and his son killed him,

1312
00:55:52.640 --> 00:55:53.480
<v Robyn Williams>and his sister.

1313
00:55:54.040 --> 00:55:57.300
<v Robyn Williams>There is a clear relationship between some drugs

1314
00:55:57.300 --> 00:55:58.560
<v Robyn Williams>and results,

1315
00:55:59.100 --> 00:56:00.580
<v Robyn Williams>that seems to be important.

1316
00:56:00.940 --> 00:56:03.620
<v Gary Greenberg>Yes, and the thing that we have to bear in mind

1317
00:56:03.620 --> 00:56:05.600
<v Gary Greenberg>is that we don't understand that.

1318
00:56:05.880 --> 00:56:06.740
<v Gary Greenberg>That's the problem.

1319
00:56:06.880 --> 00:56:08.020
<v Gary Greenberg>It's not that they don't work,

1320
00:56:08.060 --> 00:56:09.900
<v Gary Greenberg>it's that they don't work all the time.

1321
00:56:10.580 --> 00:56:12.360
<v Gary Greenberg>You know, penicillin works most of the time.

1322
00:56:12.520 --> 00:56:13.320
<v Gary Greenberg>And when it doesn't,

1323
00:56:13.320 --> 00:56:14.640
<v Gary Greenberg>you can actually see it not working.

1324
00:56:14.840 --> 00:56:16.740
<v Gary Greenberg>You can look and it's not penetrating anything.

1325
00:56:16.820 --> 00:56:18.380
<v Gary Greenberg>Yeah, penicillin penetrates the cell wall.

1326
00:56:18.620 --> 00:56:20.180
<v Gary Greenberg>You can see it not working.

1327
00:56:21.320 --> 00:56:22.560
<v Gary Greenberg>With psychiatric drugs,

1328
00:56:22.740 --> 00:56:24.540
<v Gary Greenberg>nobody understands why they work,

1329
00:56:24.700 --> 00:56:26.280
<v Gary Greenberg>and therefore why not,

1330
00:56:26.340 --> 00:56:27.360
<v Gary Greenberg>you can't predict.

1331
00:56:27.860 --> 00:56:29.360
<v Gary Greenberg>That's why people who take antidepressants,

1332
00:56:30.420 --> 00:56:31.620
<v Gary Greenberg>or antipsychotic drugs,

1333
00:56:32.320 --> 00:56:33.500
<v Gary Greenberg>there's trial and error,

1334
00:56:33.580 --> 00:56:35.380
<v Gary Greenberg>and there's huge disruptions that go on

1335
00:56:35.380 --> 00:56:37.580
<v Gary Greenberg>as a result of the trial and error.

1336
00:56:37.720 --> 00:56:39.560
<v Gary Greenberg>One other thing to point out is that

1337
00:56:39.560 --> 00:56:41.880
<v Gary Greenberg>one thing we do know about the way they work

1338
00:56:41.880 --> 00:56:43.200
<v Gary Greenberg>is that the brain is plastic,

1339
00:56:43.480 --> 00:56:46.500
<v Gary Greenberg>and altering the metabolism of a particular part of the brain,

1340
00:56:46.640 --> 00:56:47.760
<v Gary Greenberg>or system in the brain,

1341
00:56:47.860 --> 00:56:49.940
<v Gary Greenberg>is going to change the structure of the brain.

1342
00:56:50.240 --> 00:56:54.560
<v Gary Greenberg>So, we know that there's a lot of burden in these drugs,

1343
00:56:54.660 --> 00:56:56.980
<v Gary Greenberg>and we haven't quite figured out how to specify

1344
00:56:56.980 --> 00:56:58.700
<v Gary Greenberg>what the benefit is.

1345
00:56:58.840 --> 00:56:59.040
<v Robyn Williams>Yeah.

1346
00:56:59.260 --> 00:57:00.720
<v Robyn Williams>I'm going to be slightly fascist

1347
00:57:00.720 --> 00:57:02.460
<v Robyn Williams>and go till quarter to six,

1348
00:57:03.160 --> 00:57:04.220
<v Robyn Williams>you can always leave,

1349
00:57:04.360 --> 00:57:05.340
<v Robyn Williams>for Q&A.

1350
00:57:05.440 --> 00:57:07.220
<v Robyn Williams>I've got a microphone here,

1351
00:57:07.320 --> 00:57:08.680
<v Robyn Williams>there's a microphone at the back.

1352
00:57:08.800 --> 00:57:10.140
<v Robyn Williams>Would you put your hands up,

1353
00:57:10.180 --> 00:57:11.560
<v Robyn Williams>and no soliloquies please.

1354
00:57:12.140 --> 00:57:13.580
<v Robyn Williams>Just nice quick questions.

1355
00:57:13.700 --> 00:57:15.480
<v Robyn Williams>One at the back where you are,

1356
00:57:15.640 --> 00:57:18.460
<v Robyn Williams>and I'll be down here to follow up.

1357
00:57:21.080 --> 00:57:22.200
<v Robyn Williams>So, please.

1358
00:57:22.560 --> 00:57:22.900
<v Audience>Hello.

1359
00:57:23.260 --> 00:57:23.820
<v Audience>Hi.

1360
00:57:23.820 --> 00:57:26.840
<v Audience>I'm really interested in how these

1361
00:57:26.980 --> 00:57:28.540
<v Audience>drug companies are backing out now.

1362
00:57:28.740 --> 00:57:29.720
<v Audience>What are they doing?

1363
00:57:30.100 --> 00:57:30.500
<v Gary Greenberg>Nothing.

1364
00:57:30.640 --> 00:57:31.580
<v Gary Greenberg>I mean, to back out,

1365
00:57:31.600 --> 00:57:33.000
<v Gary Greenberg>all you do is fire the scientists,

1366
00:57:33.120 --> 00:57:35.000
<v Gary Greenberg>or tell them to go work on something else.

1367
00:57:35.920 --> 00:57:36.720
<v Audience>Yeah, so...

1368
00:57:36.720 --> 00:57:38.020
<v Gary Greenberg>And abandon the pipeline,

1369
00:57:38.920 --> 00:57:41.020
<v Gary Greenberg>and if you're in clinical trials,

1370
00:57:41.060 --> 00:57:41.700
<v Gary Greenberg>end the trial.

1371
00:57:41.840 --> 00:57:42.760
<v Gary Greenberg>All of that's been done.

1372
00:57:43.760 --> 00:57:45.520
<v Robyn Williams>Am I allowed to make a personal,

1373
00:57:45.680 --> 00:57:47.800
<v Robyn Williams>slightly nepotistic,

1374
00:57:47.980 --> 00:57:49.420
<v Robyn Williams>I have a nephew in Britain,

1375
00:57:50.240 --> 00:57:51.460
<v Robyn Williams>called Ben Goldacre,

1376
00:57:51.600 --> 00:57:52.320
<v Robyn Williams>who wrote a book,

1377
00:57:52.400 --> 00:57:53.780
<v Robyn Williams>well, first of all, Bad Science,

1378
00:57:53.900 --> 00:57:55.120
<v Robyn Williams>and then he wrote Bad Pharma.

1379
00:57:55.120 --> 00:57:57.200
<v Robyn Williams>Bad Pharma, PH,

1380
00:57:57.740 --> 00:57:59.480
<v Robyn Williams>is all about the drug trials.

1381
00:57:59.720 --> 00:58:00.240
<v Robyn Williams>He's your nephew?

1382
00:58:00.520 --> 00:58:01.040
<v Robyn Williams>He's my nephew.

1383
00:58:01.260 --> 00:58:05.100
<v Robyn Williams>And how they hide the ones that don't work.

1384
00:58:05.840 --> 00:58:08.420
<v Robyn Williams>And I said to him when I went to his house

1385
00:58:08.420 --> 00:58:09.760
<v Robyn Williams>three weeks ago in London,

1386
00:58:09.940 --> 00:58:11.520
<v Robyn Williams>how do you not get sued?

1387
00:58:11.660 --> 00:58:12.060
<v Robyn Williams>He said,

1388
00:58:12.200 --> 00:58:15.120
<v Robyn Williams>I marshal the evidence in scientific papers.

1389
00:58:15.380 --> 00:58:16.460
<v Robyn Williams>And the drug companies,

1390
00:58:16.520 --> 00:58:17.700
<v Robyn Williams>to answer your question in many ways,

1391
00:58:17.860 --> 00:58:20.840
<v Robyn Williams>are frightened of the evidence that's against them.

1392
00:58:20.900 --> 00:58:22.840
<v Gary Greenberg>Yeah, this is a really important point.

1393
00:58:23.140 --> 00:58:24.640
<v Gary Greenberg>They're not just pulling out

1394
00:58:24.640 --> 00:58:26.520
<v Gary Greenberg>because they don't see any future in this myth.

1395
00:58:26.960 --> 00:58:29.820
<v Gary Greenberg>They're also taking a huge hit,

1396
00:58:29.920 --> 00:58:31.120
<v Gary Greenberg>PR-wise,

1397
00:58:31.420 --> 00:58:36.020
<v Gary Greenberg>on these drugs that have these embarrassingly poor results.

1398
00:58:36.280 --> 00:58:37.880
<v Gary Greenberg>You know, now that we have in the States

1399
00:58:37.880 --> 00:58:39.680
<v Gary Greenberg>all the FDA data is public,

1400
00:58:39.840 --> 00:58:41.720
<v Gary Greenberg>and now we know that

1401
00:58:43.060 --> 00:58:44.940
<v Gary Greenberg>most of the antidepressants, anyway,

1402
00:58:45.180 --> 00:58:47.740
<v Gary Greenberg>barely distinguish themselves from the placebos.

1403
00:58:48.080 --> 00:58:50.580
<v Gary Greenberg>And the drug companies are embarrassed.

1404
00:58:50.740 --> 00:58:52.200
<v Gary Greenberg>It looks bad for them.

1405
00:58:52.620 --> 00:58:53.500
<v Audience>So there's...

1406
00:58:53.500 --> 00:58:53.840
<v Audience>Over here.

1407
00:58:54.640 --> 00:58:56.500
<v Audience>There's not much publicity about that.

1408
00:58:56.620 --> 00:58:58.880
<v Audience>You know, I'm pretty familiar with, like,

1409
00:58:58.940 --> 00:58:59.880
<v Audience>mental health services,

1410
00:58:59.980 --> 00:59:02.440
<v Audience>and they're pumping out the drugs as much as they can.

1411
00:59:02.540 --> 00:59:04.800
<v Audience>So I'm just trying to make the connection.

1412
00:59:05.140 --> 00:59:06.280
<v Gary Greenberg>Okay, well, let's make a distinction

1413
00:59:06.280 --> 00:59:07.880
<v Gary Greenberg>between the drugs that are already approved

1414
00:59:08.660 --> 00:59:11.100
<v Gary Greenberg>and can be pumped out as fast as they can

1415
00:59:11.100 --> 00:59:13.500
<v Gary Greenberg>and cost 30 cents and charge $30,

1416
00:59:14.000 --> 00:59:15.900
<v Gary Greenberg>and the drugs that are being developed.

1417
00:59:16.720 --> 00:59:19.180
<v Gary Greenberg>So what I'm talking about are the drugs being developed.

1418
00:59:19.720 --> 00:59:21.240
<v Gary Greenberg>Nobody's going to stop making Prozac

1419
00:59:22.240 --> 00:59:24.440
<v Gary Greenberg>any more than they're going to stop printing money.

1420
00:59:24.440 --> 00:59:25.320
<v Gary Greenberg>Please.

1421
00:59:26.540 --> 00:59:27.780
<v Audience>Yes, I was just interested,

1422
00:59:27.940 --> 00:59:29.640
<v Audience>when you said about your patients,

1423
00:59:29.800 --> 00:59:31.360
<v Audience>you were saying, like, you know, pick your diagnosis,

1424
00:59:31.360 --> 00:59:34.140
<v Audience>because the insurance company needs a label.

1425
00:59:34.920 --> 00:59:35.840
<v Audience>Just a minor incident,

1426
00:59:36.060 --> 00:59:38.160
<v Audience>it's currently with the education department,

1427
00:59:38.280 --> 00:59:40.900
<v Audience>so I'm also thinking how the DSM

1428
00:59:40.900 --> 00:59:42.360
<v Audience>is used by other organisations,

1429
00:59:42.580 --> 00:59:45.200
<v Audience>such as other agencies, particularly in education,

1430
00:59:45.500 --> 00:59:46.860
<v Audience>to provide a label to kids

1431
00:59:46.860 --> 00:59:49.020
<v Audience>before you'll give them any kind of support.

1432
00:59:49.360 --> 00:59:49.660
<v Audience>Right.

1433
00:59:50.240 --> 00:59:51.400
<v Audience>It's just been that recently,

1434
00:59:51.920 --> 00:59:54.420
<v Audience>with interest, my nephew is highly gifted,

1435
00:59:54.420 --> 00:59:55.920
<v Audience>which we knew before he went to school.

1436
00:59:56.060 --> 00:59:56.980
<v Audience>When he went to school,

1437
00:59:57.000 --> 00:59:58.560
<v Audience>we discovered he had some learning difficulties.

1438
00:59:58.980 --> 01:00:00.640
<v Audience>Because he has both, it's suddenly like,

1439
01:00:00.760 --> 01:00:02.000
<v Audience>you must be Asperger's.

1440
01:00:02.080 --> 01:00:04.220
<v Audience>So we need to put you in an Asperger's lab.

1441
01:00:04.300 --> 01:00:05.360
<v Audience>Please go and get a diagnosis,

1442
01:00:05.500 --> 01:00:07.320
<v Audience>because then we can give you some support.

1443
01:00:07.520 --> 01:00:10.520
<v Audience>If you don't, we can't provide you what you need,

1444
01:00:11.000 --> 01:00:12.500
<v Audience>your help you need for learning.

1445
01:00:12.580 --> 01:00:14.100
<v Audience>We can't provide you with any extra support.

1446
01:00:14.200 --> 01:00:15.400
<v Audience>We can't provide you with extra time.

1447
01:00:15.440 --> 01:00:16.360
<v Audience>We can't provide you with anything.

1448
01:00:17.620 --> 01:00:19.440
<v Audience>And we said basically, no,

1449
01:00:19.560 --> 01:00:22.420
<v Audience>because all the people we have gone to have basically said,

1450
01:00:22.480 --> 01:00:23.420
<v Audience>no, you don't need Asperger's.

1451
01:00:23.460 --> 01:00:26.600
<v Audience>You just need this support and this support,

1452
01:00:26.760 --> 01:00:27.700
<v Audience>and he'll be okay.

1453
01:00:27.960 --> 01:00:28.180
<v Gary Greenberg>Right.

1454
01:00:28.220 --> 01:00:30.160
<v Gary Greenberg>Well, let me respond to that,

1455
01:00:30.220 --> 01:00:31.480
<v Gary Greenberg>because it's a really important point.

1456
01:00:31.940 --> 01:00:35.280
<v Gary Greenberg>The impact of the DSM is everywhere,

1457
01:00:35.480 --> 01:00:37.060
<v Gary Greenberg>including the school systems.

1458
01:00:37.200 --> 01:00:40.400
<v Gary Greenberg>And what we have there is an example of something,

1459
01:00:40.520 --> 01:00:41.920
<v Gary Greenberg>you know, what I said before,

1460
01:00:41.980 --> 01:00:44.800
<v Gary Greenberg>that the magic bullet model taught us

1461
01:00:44.800 --> 01:00:46.900
<v Gary Greenberg>that diseases are forms of suffering

1462
01:00:46.900 --> 01:00:48.040
<v Gary Greenberg>that are caused by a biological,

1463
01:00:48.920 --> 01:00:50.520
<v Gary Greenberg>identifiable biological pathogen.

1464
01:00:50.560 --> 01:00:52.100
<v Gary Greenberg>Actually, what a disease is,

1465
01:00:52.820 --> 01:00:53.300
<v Gary Greenberg>is,

1466
01:00:53.460 --> 01:00:55.940
<v Gary Greenberg>is a form of suffering that we decide as a society

1467
01:00:55.940 --> 01:00:57.700
<v Gary Greenberg>to devote resources to relieving.

1468
01:00:58.240 --> 01:01:00.080
<v Gary Greenberg>And in the case of Asperger's,

1469
01:01:00.100 --> 01:01:02.320
<v Gary Greenberg>Asperger's was a tremendously successful diagnosis.

1470
01:01:02.540 --> 01:01:04.340
<v Gary Greenberg>As critical as I am of the DSM,

1471
01:01:05.620 --> 01:01:06.960
<v Gary Greenberg>diagnoses like Asperger's,

1472
01:01:07.000 --> 01:01:09.240
<v Gary Greenberg>if you look at them the way I just suggested,

1473
01:01:10.540 --> 01:01:11.460
<v Gary Greenberg>provide services.

1474
01:01:11.680 --> 01:01:13.240
<v Gary Greenberg>They attract services to people.

1475
01:01:13.460 --> 01:01:15.700
<v Gary Greenberg>That to me is a totally legitimate function.

1476
01:01:16.080 --> 01:01:16.820
<v Gary Greenberg>Now, interestingly,

1477
01:01:17.140 --> 01:01:18.800
<v Gary Greenberg>Asperger's is no longer in the DSM

1478
01:01:19.460 --> 01:01:20.600
<v Gary Greenberg>because it was too successful.

1479
01:01:20.980 --> 01:01:22.760
<v Gary Greenberg>And this also became an embarrassment.

1480
01:01:23.280 --> 01:01:24.220
<v Gary Greenberg>Psychiatry is a terrible,

1481
01:01:24.320 --> 01:01:24.620
<v Gary Greenberg>you know,

1482
01:01:24.640 --> 01:01:25.460
<v Gary Greenberg>inferiority complex.

1483
01:01:25.620 --> 01:01:28.300
<v Gary Greenberg>And they're always trying to repair their image.

1484
01:01:29.160 --> 01:01:29.920
<v Robyn Williams>Please, over there.

1485
01:01:30.740 --> 01:01:33.420
<v Audience>Yeah, the latest DSM redefines addiction

1486
01:01:34.040 --> 01:01:36.260
<v Audience>and also includes a behavioral addiction,

1487
01:01:36.420 --> 01:01:37.700
<v Audience>I think gambling for the first time.

1488
01:01:37.940 --> 01:01:39.600
<v Audience>I just wondered on your views

1489
01:01:39.600 --> 01:01:41.100
<v Audience>on the disease model of addiction

1490
01:01:41.100 --> 01:01:42.360
<v Audience>and the debate around that.

1491
01:01:42.500 --> 01:01:43.800
<v Audience>Because it seems to be a good example

1492
01:01:43.800 --> 01:01:44.960
<v Audience>of the kind of thing you're talking about.

1493
01:01:45.100 --> 01:01:45.460
<v Gary Greenberg>Yes.

1494
01:01:45.860 --> 01:01:48.060
<v Gary Greenberg>So, I'll go back to the comment I made before

1495
01:01:48.060 --> 01:01:48.660
<v Gary Greenberg>about biology.

1496
01:01:48.880 --> 01:01:51.700
<v Gary Greenberg>We may be able to find some biological correlates.

1497
01:01:51.700 --> 01:01:52.580
<v Gary Greenberg>In the case of addiction,

1498
01:01:52.800 --> 01:01:54.040
<v Gary Greenberg>what they've discovered is,

1499
01:01:54.120 --> 01:01:54.700
<v Gary Greenberg>they think,

1500
01:01:54.820 --> 01:01:56.960
<v Gary Greenberg>the biological correlates of craving.

1501
01:01:58.060 --> 01:02:00.180
<v Gary Greenberg>And that that will characterize addiction.

1502
01:02:00.360 --> 01:02:01.600
<v Gary Greenberg>If you crave the drug,

1503
01:02:01.660 --> 01:02:02.680
<v Gary Greenberg>then you'll be addicted.

1504
01:02:02.840 --> 01:02:03.740
<v Gary Greenberg>But the whole move

1505
01:02:04.260 --> 01:02:07.740
<v Gary Greenberg>to bring behavioral addiction into the DSM

1506
01:02:07.740 --> 01:02:09.740
<v Gary Greenberg>and to redefine addiction

1507
01:02:09.740 --> 01:02:11.340
<v Gary Greenberg>is all about preparing the way

1508
01:02:11.340 --> 01:02:12.680
<v Gary Greenberg>for addiction to become

1509
01:02:12.680 --> 01:02:15.120
<v Gary Greenberg>the first biologically defined disorder.

1510
01:02:15.720 --> 01:02:17.400
<v Gary Greenberg>Now, an interesting story here

1511
01:02:17.400 --> 01:02:18.740
<v Gary Greenberg>is that they had an opportunity

1512
01:02:18.740 --> 01:02:20.480
<v Gary Greenberg>to put a biologically defined disorder

1513
01:02:20.480 --> 01:02:21.680
<v Gary Greenberg>in the DSM this summer

1514
01:02:21.700 --> 01:02:21.840
<v Gary Greenberg>for the first time.

1515
01:02:22.060 --> 01:02:23.880
<v Gary Greenberg>It would have been called melancholia.

1516
01:02:24.080 --> 01:02:25.840
<v Gary Greenberg>It's a really old diagnosis.

1517
01:02:26.300 --> 01:02:28.440
<v Gary Greenberg>And melancholia is a form of depression

1518
01:02:28.440 --> 01:02:30.100
<v Gary Greenberg>that has a biological...

1519
01:02:30.100 --> 01:02:30.940
<v Gary Greenberg>biochemical signature.

1520
01:02:31.260 --> 01:02:32.460
<v Gary Greenberg>It has everything they've wanted

1521
01:02:32.460 --> 01:02:33.700
<v Gary Greenberg>for 150 years.

1522
01:02:34.020 --> 01:02:34.840
<v Gary Greenberg>It has...

1523
01:02:35.700 --> 01:02:36.660
<v Gary Greenberg>You can test for it

1524
01:02:36.660 --> 01:02:38.660
<v Gary Greenberg>with cortisone basically.

1525
01:02:39.080 --> 01:02:41.760
<v Gary Greenberg>It has a unique sleep pattern.

1526
01:02:41.920 --> 01:02:42.700
<v Gary Greenberg>It responds differentially

1527
01:02:43.260 --> 01:02:44.040
<v Gary Greenberg>to certain treatments.

1528
01:02:44.240 --> 01:02:45.620
<v Gary Greenberg>And it has a very specific

1529
01:02:45.620 --> 01:02:46.640
<v Gary Greenberg>pattern of symptoms.

1530
01:02:46.820 --> 01:02:48.200
<v Gary Greenberg>It's completely spot on.

1531
01:02:48.360 --> 01:02:49.860
<v Gary Greenberg>The guys who suggested it

1532
01:02:49.860 --> 01:02:50.840
<v Gary Greenberg>including Gordon Parker

1533
01:02:50.840 --> 01:02:51.680
<v Gary Greenberg>from here in Australia

1534
01:02:51.700 --> 01:02:54.800
<v Gary Greenberg>Australia, were not even considered.

1535
01:02:55.060 --> 01:02:58.580
<v Gary Greenberg>I mean, prominent psychiatrists from around the world asked them to even look at it.

1536
01:02:58.740 --> 01:03:02.480
<v Gary Greenberg>They wouldn't look at it, and in correspondence with him, which somebody made the mistake

1537
01:03:02.480 --> 01:03:08.280
<v Gary Greenberg>of giving me, the reason was because even though the guy on the committee fielding this

1538
01:03:08.280 --> 01:03:13.520
<v Gary Greenberg>request agreed, he thought it would be a bad idea because it would be the only diagnosis

1539
01:03:13.520 --> 01:03:15.240
<v Gary Greenberg>like it in the DSM.

1540
01:03:15.540 --> 01:03:18.200
<v Gary Greenberg>In other words, it would make the whole rest of the DSM look bad.

1541
01:03:19.100 --> 01:03:21.460
<v Gary Greenberg>No, he didn't say that, but I think it's a fair inference.

1542
01:03:21.720 --> 01:03:22.080
<v Robyn Williams>Yes, please.

1543
01:03:22.760 --> 01:03:29.020
<v Audience>What would be the process for altering medical records if you were somebody that was diagnosed

1544
01:03:29.020 --> 01:03:33.820
<v Audience>with manic depression incorrectly, and as you say, that goes on a record, and then you

1545
01:03:33.820 --> 01:03:39.360
<v Audience>realize maybe later you're one of these children, and you go, this isn't right, and I don't

1546
01:03:39.360 --> 01:03:43.260
<v Audience>know enough about the consequences of the medical records, what they mean, and what

1547
01:03:43.260 --> 01:03:46.060
<v Audience>they can do, but how would a person go about changing it?

1548
01:03:46.060 --> 01:03:47.500
<v Gary Greenberg>Well, I don't know how it works in Australia.

1549
01:03:47.500 --> 01:03:49.160
<v Gary Greenberg>But in the States, it's impossible.

1550
01:03:49.500 --> 01:03:50.380
<v Gary Greenberg>It's indelible.

1551
01:03:50.540 --> 01:03:52.760
<v Gary Greenberg>Because it's not supposed to be a matter of contention.

1552
01:03:52.880 --> 01:03:55.360
<v Gary Greenberg>Just because you don't like your diagnosis doesn't mean you should be able to kick it

1553
01:03:55.360 --> 01:03:56.200
<v Gary Greenberg>out of your folder, right?

1554
01:03:57.200 --> 01:04:02.100
<v Gary Greenberg>And I'm not saying you shouldn't, but if you did that, then you'd be basically admitting

1555
01:04:02.100 --> 01:04:04.340
<v Gary Greenberg>these aren't medical diagnoses at all.

1556
01:04:04.480 --> 01:04:05.640
<v Gary Greenberg>Can another doctor kick it out?

1557
01:04:05.780 --> 01:04:06.040
<v Gary Greenberg>No.

1558
01:04:06.140 --> 01:04:10.260
<v Gary Greenberg>And I have a patient, a woman who's desperately ill with a million different kinds of diseases,

1559
01:04:11.980 --> 01:04:13.600
<v Gary Greenberg>and it's a nightmare of a story.

1560
01:04:14.160 --> 01:04:16.140
<v Gary Greenberg>Whenever she goes into the hospital, there's...

1561
01:04:17.480 --> 01:04:17.860
<v Gary Greenberg>There's questions.

1562
01:04:17.980 --> 01:04:19.200
<v Gary Greenberg>Is she making this up?

1563
01:04:19.380 --> 01:04:19.840
<v Gary Greenberg>Is she...

1564
01:04:19.840 --> 01:04:22.500
<v Gary Greenberg>Because this is what doctors often do, and they can't understand it.

1565
01:04:22.540 --> 01:04:23.500
<v Gary Greenberg>They say, oh, it must be psychiatric.

1566
01:04:24.040 --> 01:04:30.660
<v Gary Greenberg>And one time, she took a psychological test and was diagnosed with some mental illness.

1567
01:04:30.860 --> 01:04:36.080
<v Gary Greenberg>And I'm telling you, this woman's medical charts require a hand truck to move around,

1568
01:04:36.200 --> 01:04:37.860
<v Gary Greenberg>but somehow that diagnosis surfaces.

1569
01:04:38.260 --> 01:04:43.840
<v Gary Greenberg>Almost every time she gets into a new hospital, I get a phone call from a clinician or a doctor.

1570
01:04:44.060 --> 01:04:45.180
<v Gary Greenberg>You know, is...

1571
01:04:45.180 --> 01:04:46.420
<v Gary Greenberg>What's going on with her?

1572
01:04:46.520 --> 01:04:47.460
<v Gary Greenberg>Does she really have...

1573
01:04:47.480 --> 01:04:47.640
<v Gary Greenberg>Whatever.

1574
01:04:47.840 --> 01:04:49.400
<v Gary Greenberg>I don't remember what the diagnosis is.

1575
01:04:49.520 --> 01:04:52.340
<v Gary Greenberg>And it's like, oh, my God, this was 15 years ago.

1576
01:04:52.580 --> 01:04:56.660
<v Gary Greenberg>So the answer is, you should be really careful when your shrink says to you,

1577
01:04:56.740 --> 01:05:00.280
<v Gary Greenberg>well, what diagnosis do you want, or would you like to pay for this in cash?

1578
01:05:01.700 --> 01:05:02.100
<v Gary Greenberg>Thanks.

1579
01:05:03.120 --> 01:05:04.760
<v Audience>Your history is compelling.

1580
01:05:05.040 --> 01:05:09.980
<v Audience>Your allusion to autoimmune disease as having a similar kind of problem.

1581
01:05:10.380 --> 01:05:13.020
<v Audience>I've been thinking about this, and it seems to me that...

1582
01:05:13.920 --> 01:05:17.460
<v Audience>Well, I think possibly one of the problems is the mechanism,

1583
01:05:17.480 --> 01:05:19.660
<v Audience>the mechanism of consensus, that we need consensus,

1584
01:05:20.620 --> 01:05:24.400
<v Audience>and that the organs that make consensus and defend consensus

1585
01:05:24.400 --> 01:05:26.760
<v Audience>are the things that lead us down all these blind alleys continuously.

1586
01:05:27.240 --> 01:05:28.540
<v Audience>What do you mean?

1587
01:05:28.660 --> 01:05:29.640
<v Audience>Did you say consensus?

1588
01:05:30.040 --> 01:05:30.380
<v Audience>Yes.

1589
01:05:30.560 --> 01:05:31.000
<v Audience>Tell me what you mean.

1590
01:05:31.000 --> 01:05:36.600
<v Audience>The consensus that our version of crazy is now...

1591
01:05:36.600 --> 01:05:36.960
<v Audience>Oh, I see.

1592
01:05:37.020 --> 01:05:40.020
<v Audience>...gets developed by this system,

1593
01:05:40.780 --> 01:05:46.300
<v Audience>because as a herd species, we need a thing to follow.

1594
01:05:46.520 --> 01:05:46.680
<v Audience>Right.

1595
01:05:47.480 --> 01:05:49.720
<v Gary Greenberg>Yeah, that's actually a brilliant idea,

1596
01:05:49.900 --> 01:05:51.640
<v Gary Greenberg>which I'm jealous that I didn't come up with.

1597
01:05:52.700 --> 01:05:55.260
<v Gary Greenberg>I don't have anything to say to that, except that's great.

1598
01:05:56.300 --> 01:05:57.280
<v Gary Greenberg>Anyone over here?

1599
01:05:57.520 --> 01:05:57.940
<v Audience>Hi.

1600
01:05:58.060 --> 01:06:00.140
<v Audience>I was just wondering, it's obviously problematic

1601
01:06:00.140 --> 01:06:03.100
<v Audience>that the DSM has a number of symptoms

1602
01:06:03.100 --> 01:06:06.380
<v Audience>that correlate to many different disorders,

1603
01:06:07.120 --> 01:06:10.460
<v Audience>and with the increase of anxiety and depression rates,

1604
01:06:10.760 --> 01:06:15.540
<v Audience>how common does something have to be before it's considered normal?

1605
01:06:15.700 --> 01:06:17.180
<v Audience>And just on the topic of...

1606
01:06:17.180 --> 01:06:17.460
<v Audience>And just on the topic of...

1607
01:06:17.480 --> 01:06:18.900
<v Audience>I think it's interesting.

1608
01:06:19.100 --> 01:06:22.060
<v Audience>I think it's a Buddhist philosophy that life is suffering,

1609
01:06:22.220 --> 01:06:25.300
<v Audience>and once you accept that, then it's less problematic,

1610
01:06:25.460 --> 01:06:27.940
<v Audience>and you can just accept it and just go with the flow.

1611
01:06:28.040 --> 01:06:29.200
<v Audience>I just wanted your thoughts on that.

1612
01:06:30.080 --> 01:06:31.440
<v Gary Greenberg>Okay, so what was the first one again?

1613
01:06:31.520 --> 01:06:31.760
<v Gary Greenberg>I'm sorry.

1614
01:06:31.900 --> 01:06:33.120
<v Gary Greenberg>It was an interesting question.

1615
01:06:33.220 --> 01:06:33.460
<v Gary Greenberg>Oh, yeah.

1616
01:06:33.540 --> 01:06:34.680
<v Gary Greenberg>At what point does it become normal?

1617
01:06:34.760 --> 01:06:37.800
<v Gary Greenberg>Well, statistically, when you exceed 50%, right?

1618
01:06:38.220 --> 01:06:40.700
<v Gary Greenberg>But at this point, I think it's fair to say

1619
01:06:40.700 --> 01:06:44.800
<v Gary Greenberg>that the burden is on psychiatry already to prove

1620
01:06:45.540 --> 01:06:49.440
<v Gary Greenberg>that the system of diagnosis can make that distinction.

1621
01:06:49.640 --> 01:06:52.380
<v Gary Greenberg>At the moment, it can't, and that is the problem.

1622
01:06:52.780 --> 01:06:56.340
<v Gary Greenberg>One of the things that they're trying to do to replace the DSM

1623
01:06:56.340 --> 01:06:59.400
<v Gary Greenberg>is they're trying to look at the neurocircuitry of specific symptoms,

1624
01:07:00.100 --> 01:07:04.180
<v Gary Greenberg>and I think the hope there is that they can find normal fear

1625
01:07:05.100 --> 01:07:06.360
<v Gary Greenberg>and pathological fear,

1626
01:07:06.520 --> 01:07:09.980
<v Gary Greenberg>and so put you in a brain scanner, or normal desire and craving,

1627
01:07:10.660 --> 01:07:12.120
<v Gary Greenberg>and they don't have to listen to you anymore.

1628
01:07:12.500 --> 01:07:14.060
<v Gary Greenberg>They can just, like, look at your brain,

1629
01:07:14.060 --> 01:07:14.760
<v Gary Greenberg>and they can find normal fear.

1630
01:07:14.760 --> 01:07:16.500
<v Gary Greenberg>The guy who presented this at the last meeting

1631
01:07:16.500 --> 01:07:18.360
<v Gary Greenberg>of the American Psychiatric Association said,

1632
01:07:18.420 --> 01:07:20.460
<v Gary Greenberg>yeah, I know it means everybody's going to have to have a brain scanner

1633
01:07:20.460 --> 01:07:22.540
<v Gary Greenberg>in the office, but the price is coming down.

1634
01:07:25.040 --> 01:07:27.880
<v Gary Greenberg>And the second, yeah, I mean, one of the things

1635
01:07:27.880 --> 01:07:30.340
<v Gary Greenberg>that I think we haven't done very well,

1636
01:07:30.420 --> 01:07:31.540
<v Gary Greenberg>we talk a lot about resilience,

1637
01:07:32.420 --> 01:07:36.520
<v Gary Greenberg>but resilience is not so much the absence of suffering

1638
01:07:36.520 --> 01:07:38.820
<v Gary Greenberg>as the tolerance for suffering,

1639
01:07:38.980 --> 01:07:42.120
<v Gary Greenberg>and I think that therapists have led the way

1640
01:07:42.120 --> 01:07:44.040
<v Gary Greenberg>to making people think that, you know,

1641
01:07:44.060 --> 01:07:45.660
<v Gary Greenberg>life should be suffering-free,

1642
01:07:45.840 --> 01:07:47.840
<v Gary Greenberg>and that if it isn't, you're doing something wrong,

1643
01:07:48.600 --> 01:07:49.820
<v Gary Greenberg>which just makes you suffer more,

1644
01:07:49.880 --> 01:07:50.560
<v Gary Greenberg>which is good for business,

1645
01:07:50.700 --> 01:07:54.080
<v Gary Greenberg>but it is not such a good idea to have out there.

1646
01:07:54.120 --> 01:07:55.380
<v Gary Greenberg>The idea that needs to be out there

1647
01:07:55.380 --> 01:07:57.200
<v Gary Greenberg>is that we've got to get a lot better,

1648
01:07:57.680 --> 01:07:59.760
<v Gary Greenberg>because God knows we're going to be facing a lot of suffering

1649
01:07:59.760 --> 01:08:00.640
<v Gary Greenberg>as time goes on.

1650
01:08:01.820 --> 01:08:02.280
<v Robyn Williams>Yes, please.

1651
01:08:03.600 --> 01:08:04.560
<v Robyn Williams>Got one over there?

1652
01:08:04.680 --> 01:08:05.220
<v Robyn Williams>Yes, okay.

1653
01:08:05.740 --> 01:08:06.300
<v Robyn Williams>There you go.

1654
01:08:06.780 --> 01:08:07.720
<v Audience>Oh, me up here?

1655
01:08:09.440 --> 01:08:12.620
<v Audience>I hope I articulate this, so I apologize in advance.

1656
01:08:14.120 --> 01:08:15.940
<v Audience>So there seems to be,

1657
01:08:18.600 --> 01:08:20.480
<v Audience>there's one aspect of a discussion

1658
01:08:20.480 --> 01:08:25.860
<v Audience>around over-medicalizing people,

1659
01:08:26.540 --> 01:08:28.440
<v Audience>so that's the general gist.

1660
01:08:28.540 --> 01:08:33.580
<v Audience>Do you have an idea of what other conversation

1661
01:08:33.580 --> 01:08:35.000
<v Audience>there should be now?

1662
01:08:35.120 --> 01:08:36.560
<v Audience>So there's a conversation around

1663
01:08:36.560 --> 01:08:38.980
<v Audience>we shouldn't quickly diagnose,

1664
01:08:39.940 --> 01:08:42.600
<v Audience>we shouldn't be labeling too much,

1665
01:08:48.240 --> 01:08:49.300
<v Gary Greenberg>but we should be labeling too much.

1666
01:08:49.300 --> 01:08:52.460
<v Gary Greenberg>the fact that 30% of the American population

1667
01:08:52.460 --> 01:08:54.580
<v Gary Greenberg>will show up as mentally ill,

1668
01:08:54.660 --> 01:08:56.140
<v Gary Greenberg>and we take it seriously,

1669
01:08:56.820 --> 01:08:58.520
<v Gary Greenberg>and we say this isn't just nonsense,

1670
01:08:59.180 --> 01:09:01.000
<v Gary Greenberg>and this isn't manufactured epidemics.

1671
01:09:01.080 --> 01:09:02.080
<v Gary Greenberg>What this is is an indication

1672
01:09:02.080 --> 01:09:04.800
<v Gary Greenberg>that there's a lot of unhappiness,

1673
01:09:05.320 --> 01:09:07.020
<v Gary Greenberg>discontent, and suffering out there,

1674
01:09:07.740 --> 01:09:09.600
<v Gary Greenberg>but what we're doing is we're just seeing,

1675
01:09:10.240 --> 01:09:12.620
<v Gary Greenberg>we're looking at it as individual pathology

1676
01:09:12.620 --> 01:09:14.040
<v Gary Greenberg>when we might want to look at it as a pathology.

1677
01:09:14.040 --> 01:09:15.940
<v Gary Greenberg>We're looking at it as a social problem.

1678
01:09:16.280 --> 01:09:17.140
<v Gary Greenberg>So for instance,

1679
01:09:19.120 --> 01:09:20.580
<v Gary Greenberg>in the United States,

1680
01:09:20.600 --> 01:09:22.000
<v Gary Greenberg>we don't have retirement,

1681
01:09:22.260 --> 01:09:23.360
<v Gary Greenberg>we don't have tuition,

1682
01:09:23.620 --> 01:09:25.260
<v Gary Greenberg>we don't have healthcare paid for,

1683
01:09:25.360 --> 01:09:27.100
<v Gary Greenberg>and I don't mean to whine at you

1684
01:09:27.100 --> 01:09:28.240
<v Gary Greenberg>about my horrible country, but,

1685
01:09:29.620 --> 01:09:32.580
<v Gary Greenberg>and we just almost like pulled the whole world

1686
01:09:32.580 --> 01:09:35.380
<v Gary Greenberg>over a cliff because they didn't want to fund healthcare.

1687
01:09:36.040 --> 01:09:37.720
<v Gary Greenberg>Now, but the question I would have is

1688
01:09:37.720 --> 01:09:40.580
<v Gary Greenberg>how much suffering would it relieve

1689
01:09:41.140 --> 01:09:42.740
<v Gary Greenberg>if every citizen knew

1690
01:09:43.260 --> 01:09:44.020
<v Gary Greenberg>that they were going to die?

1691
01:09:44.020 --> 01:09:44.100
<v Gary Greenberg>How much suffering would it relieve

1692
01:09:44.100 --> 01:09:44.140
<v Gary Greenberg>that they were going to die?

1693
01:09:44.140 --> 01:09:44.780
<v Gary Greenberg>that we're going to get taken care of.

1694
01:09:45.860 --> 01:09:49.640
<v Gary Greenberg>And to me, it's like the answer seems to be quite obvious,

1695
01:09:50.180 --> 01:09:53.420
<v Gary Greenberg>that if basic needs are met, people suffer less,

1696
01:09:53.580 --> 01:09:55.260
<v Gary Greenberg>and those numbers might come down.

1697
01:09:56.360 --> 01:09:59.340
<v Audience>And are you yourself involved in that discussion?

1698
01:09:59.880 --> 01:10:01.840
<v Gary Greenberg>Well, I mean, yeah, I write books about it.

1699
01:10:01.980 --> 01:10:04.880
<v Gary Greenberg>But, you know, I'll be the first to admit books

1700
01:10:04.880 --> 01:10:07.520
<v Gary Greenberg>are a coward's way out, so I'm not going

1701
01:10:07.520 --> 01:10:08.500
<v Gary Greenberg>to tell you I'm doing anything.

1702
01:10:09.000 --> 01:10:09.640
<v Audience>Thank you.

1703
01:10:09.820 --> 01:10:10.500
<v Audience>Question here.

1704
01:10:12.540 --> 01:10:14.000
<v Audience>I very much agree with what you said,

1705
01:10:14.020 --> 01:10:16.700
<v Audience>and I agree with you about the social solutions to suffering.

1706
01:10:17.120 --> 01:10:21.000
<v Audience>But also, often in personal suffering,

1707
01:10:21.200 --> 01:10:24.160
<v Audience>then it's loving kindness and good attention

1708
01:10:24.160 --> 01:10:26.660
<v Audience>that will help heal suffering.

1709
01:10:26.980 --> 01:10:29.080
<v Gary Greenberg>That's right, and that's what good therapy is, right?

1710
01:10:29.240 --> 01:10:31.460
<v Gary Greenberg>And by the way, no matter what school of therapy

1711
01:10:31.460 --> 01:10:34.060
<v Gary Greenberg>people are practicing, all therapies, you know,

1712
01:10:34.100 --> 01:10:36.140
<v Gary Greenberg>there's this dodo bird effect, all have win

1713
01:10:36.140 --> 01:10:37.120
<v Gary Greenberg>and all must have prizes.

1714
01:10:38.320 --> 01:10:40.980
<v Gary Greenberg>Because as long as a therapist believes what they're doing,

1715
01:10:41.060 --> 01:10:43.440
<v Gary Greenberg>and they're reasonably competent and humane at it,

1716
01:10:43.440 --> 01:10:45.780
<v Gary Greenberg>they help because they're providing.

1717
01:10:46.060 --> 01:10:50.220
<v Gary Greenberg>And in a world where these things are hard to come by,

1718
01:10:50.320 --> 01:10:52.200
<v Gary Greenberg>attention, loving kindness, and so on,

1719
01:10:53.500 --> 01:10:55.380
<v Gary Greenberg>to have to pay money to go and get it,

1720
01:10:55.400 --> 01:10:56.240
<v Gary Greenberg>in some ways that's pathetic.

1721
01:10:56.840 --> 01:10:57.480
<v Gary Greenberg>It's awful.

1722
01:10:57.860 --> 01:11:00.180
<v Gary Greenberg>If we had a world that was more like I would,

1723
01:11:00.200 --> 01:11:02.440
<v Gary Greenberg>I'd be out of at least that one of my jobs,

1724
01:11:02.540 --> 01:11:04.000
<v Gary Greenberg>which would be okay with me.

1725
01:11:04.400 --> 01:11:05.100
<v Audience>Up the back.

1726
01:11:05.840 --> 01:11:08.140
<v Audience>If you can, you were talking just before about,

1727
01:11:08.260 --> 01:11:12.580
<v Audience>like, the social problems compared to America with,

1728
01:11:12.580 --> 01:11:15.520
<v Audience>you know, healthcare and retirement and things like that.

1729
01:11:15.660 --> 01:11:19.960
<v Audience>Then how do you explain such high rates of suicide

1730
01:11:19.960 --> 01:11:24.260
<v Audience>and depression in places like Scandinavia and Australia?

1731
01:11:24.640 --> 01:11:26.420
<v Gary Greenberg>Well, I don't know what the deal is in Australia,

1732
01:11:26.560 --> 01:11:29.640
<v Gary Greenberg>but I know that the rates of suicide in Scandinavia

1733
01:11:29.640 --> 01:11:33.020
<v Gary Greenberg>are higher, but I'm not sure that the rates of depression are.

1734
01:11:33.080 --> 01:11:35.000
<v Gary Greenberg>Depression and suicide aren't the same thing, right?

1735
01:11:35.420 --> 01:11:37.720
<v Gary Greenberg>And I'm not sure exactly how to explain that,

1736
01:11:37.760 --> 01:11:40.860
<v Gary Greenberg>but I also know that our ways of measuring these things

1737
01:11:40.860 --> 01:11:41.660
<v Gary Greenberg>are very...

1738
01:11:43.040 --> 01:11:43.600
<v Gary Greenberg>limited.

1739
01:11:44.420 --> 01:11:47.320
<v Gary Greenberg>The measures of things like depression

1740
01:11:47.320 --> 01:11:49.240
<v Gary Greenberg>are really hard to understand.

1741
01:11:49.480 --> 01:11:54.580
<v Gary Greenberg>On the other hand, if you ask people how happy they are,

1742
01:11:55.500 --> 01:11:59.360
<v Gary Greenberg>whatever that means, if you create scales to measure that,

1743
01:11:59.560 --> 01:12:01.480
<v Gary Greenberg>places like Scandinavia do really well.

1744
01:12:01.940 --> 01:12:04.140
<v Gary Greenberg>And by the way, I understand so does Australia.

1745
01:12:04.880 --> 01:12:06.820
<v Gary Greenberg>Although I haven't seen this myself.

1746
01:12:06.940 --> 01:12:08.580
<v Gary Greenberg>I've certainly seen the European statistics.

1747
01:12:08.980 --> 01:12:12.080
<v Gary Greenberg>So I don't suggest that what I'm saying

1748
01:12:12.080 --> 01:12:12.900
<v Gary Greenberg>has been proven.

1749
01:12:13.380 --> 01:12:15.120
<v Gary Greenberg>I'm saying that it needs to be thought about.

1750
01:12:15.540 --> 01:12:17.140
<v Gary Greenberg>We also need to think, by the way,

1751
01:12:17.200 --> 01:12:19.740
<v Gary Greenberg>we're not very good at thinking of the social ramifications

1752
01:12:19.740 --> 01:12:22.440
<v Gary Greenberg>of widespread use of drugs.

1753
01:12:22.520 --> 01:12:23.840
<v Gary Greenberg>And again, that's not just psychiatric.

1754
01:12:24.180 --> 01:12:26.440
<v Gary Greenberg>Look what's happening in the world of the microbiome.

1755
01:12:27.020 --> 01:12:29.540
<v Gary Greenberg>The treatment of bacteria by antibiotics,

1756
01:12:29.800 --> 01:12:31.600
<v Gary Greenberg>which seems like an unadulterated good thing,

1757
01:12:31.680 --> 01:12:33.380
<v Gary Greenberg>is turning out to have social consequences.

1758
01:12:34.200 --> 01:12:36.600
<v Gary Greenberg>So too, I believe, there might be social consequences

1759
01:12:36.600 --> 01:12:39.380
<v Gary Greenberg>to a large percentage of the population running around

1760
01:12:39.380 --> 01:12:41.480
<v Gary Greenberg>with their emotional...

1761
01:12:41.480 --> 01:12:42.060
<v Gary Greenberg>depression.

1762
01:12:42.060 --> 01:12:42.960
<v Gary Greenberg>Emotions suppressed.

1763
01:12:43.380 --> 01:12:44.220
<v Gary Greenberg>I don't know what they are,

1764
01:12:44.300 --> 01:12:45.900
<v Gary Greenberg>but we're not very good at thinking about that.

1765
01:12:46.300 --> 01:12:47.760
<v Robyn Williams>I'm going to ask, well, in fact,

1766
01:12:47.780 --> 01:12:49.360
<v Robyn Williams>make the last statement, then you can respond to it.

1767
01:12:49.480 --> 01:12:50.620
<v Robyn Williams>You go running, don't you?

1768
01:12:51.040 --> 01:12:51.400
<v Robyn Williams>Running?

1769
01:12:51.740 --> 01:12:52.660
<v Gary Greenberg>Do you run?

1770
01:12:52.760 --> 01:12:55.660
<v Gary Greenberg>I don't have knees for running, but I do exercise.

1771
01:12:55.840 --> 01:12:56.460
<v Gary Greenberg>You do exercise.

1772
01:12:56.620 --> 01:12:57.360
<v Gary Greenberg>Are you worried about my health?

1773
01:12:57.600 --> 01:12:58.100
<v Robyn Williams>No, no, no.

1774
01:12:58.680 --> 01:13:00.780
<v Robyn Williams>Well, to some extent, the mystery was,

1775
01:13:01.660 --> 01:13:03.080
<v Robyn Williams>here's this thing called exercise,

1776
01:13:03.260 --> 01:13:05.900
<v Robyn Williams>which seems to be so good for so many things.

1777
01:13:06.020 --> 01:13:08.740
<v Robyn Williams>And yet again, people didn't quite understand

1778
01:13:08.740 --> 01:13:10.280
<v Robyn Williams>whether there was science.

1779
01:13:10.280 --> 01:13:12.680
<v Robyn Williams>If you go running, if you take exercise,

1780
01:13:12.900 --> 01:13:14.500
<v Robyn Williams>why is depression relieved?

1781
01:13:15.120 --> 01:13:17.720
<v Robyn Williams>If you go running, why is it good for your vascular system?

1782
01:13:17.820 --> 01:13:20.460
<v Robyn Williams>If you go running, all sorts of things are improved.

1783
01:13:20.940 --> 01:13:23.780
<v Robyn Williams>And about a year ago, they found out the answer.

1784
01:13:24.240 --> 01:13:27.120
<v Robyn Williams>Because it turns out that those great big cells

1785
01:13:27.120 --> 01:13:29.940
<v Robyn Williams>that clean up the shit in every organ

1786
01:13:30.840 --> 01:13:31.820
<v Robyn Williams>make it better.

1787
01:13:32.080 --> 01:13:34.160
<v Robyn Williams>Obviously, the machine gets cleaned out,

1788
01:13:34.200 --> 01:13:36.580
<v Robyn Williams>it gets serviced through the exercise.

1789
01:13:36.980 --> 01:13:40.140
<v Robyn Williams>And amongst other things, your depression is relieved.

1790
01:13:40.140 --> 01:13:44.100
<v Robyn Williams>The second thing I wanted to mention is the Michael Marmot.

1791
01:13:44.160 --> 01:13:48.360
<v Robyn Williams>Sir Michael Marmot in Britain did the Whitehall survey.

1792
01:13:49.620 --> 01:13:53.340
<v Robyn Williams>As to which public servants, civil servants,

1793
01:13:53.380 --> 01:13:54.140
<v Robyn Williams>they call them in Britain,

1794
01:13:54.820 --> 01:13:57.220
<v Robyn Williams>suffered the most and had the longest lifespans,

1795
01:13:57.220 --> 01:14:00.380
<v Robyn Williams>it turned out that the guys at the highest level

1796
01:14:00.920 --> 01:14:02.840
<v Robyn Williams>lived longer and had less disease,

1797
01:14:02.980 --> 01:14:05.820
<v Robyn Williams>and down below were more sick.

1798
01:14:06.400 --> 01:14:08.540
<v Robyn Williams>And it was a matter of control.

1799
01:14:08.540 --> 01:14:12.240
<v Robyn Williams>The more control you have, the healthier you are,

1800
01:14:12.280 --> 01:14:14.360
<v Robyn Williams>the less, the worse off.

1801
01:14:14.380 --> 01:14:16.680
<v Gary Greenberg>The more control you have over the circumstances of your life,

1802
01:14:16.880 --> 01:14:19.520
<v Gary Greenberg>it works both physically and mentally.

1803
01:14:19.620 --> 01:14:21.520
<v Gary Greenberg>The first example is really interesting, though.

1804
01:14:21.740 --> 01:14:23.760
<v Gary Greenberg>Don't we already know that exercise is good?

1805
01:14:23.960 --> 01:14:24.260
<v Gary Greenberg>Yeah.

1806
01:14:24.500 --> 01:14:28.140
<v Gary Greenberg>So why do we have to go through this whole business?

1807
01:14:28.280 --> 01:14:29.480
<v Gary Greenberg>I mean, by the way, exercise,

1808
01:14:29.640 --> 01:14:31.800
<v Gary Greenberg>especially the large muscle repetitive exercise,

1809
01:14:32.060 --> 01:14:34.320
<v Gary Greenberg>it actually increases serotonin metabolism

1810
01:14:34.320 --> 01:14:37.340
<v Gary Greenberg>in a way that's not unlike what antidepressants do.

1811
01:14:37.820 --> 01:14:40.440
<v Gary Greenberg>And the theory, by the way, that used to be,

1812
01:14:40.500 --> 01:14:41.980
<v Gary Greenberg>and now this one's being discarded slowly,

1813
01:14:42.120 --> 01:14:42.880
<v Gary Greenberg>but I like this theory,

1814
01:14:43.000 --> 01:14:46.440
<v Gary Greenberg>was that serotonin increases neurogenesis.

1815
01:14:47.160 --> 01:14:49.060
<v Gary Greenberg>The more you have, the more brain cells you grow,

1816
01:14:49.200 --> 01:14:50.920
<v Gary Greenberg>and the depression was some kind of a lack of that.

1817
01:14:51.040 --> 01:14:54.720
<v Gary Greenberg>But the point is, there's an awful lot of this focus

1818
01:14:54.720 --> 01:14:57.400
<v Gary Greenberg>on finding biological findings that's unnecessary.

1819
01:14:58.320 --> 01:15:00.980
<v Gary Greenberg>It's like, come on, you know exercise is good for you.

1820
01:15:01.020 --> 01:15:02.480
<v Gary Greenberg>Do you really need an MRI to prove this?

1821
01:15:03.640 --> 01:15:05.580
<v Robyn Williams>Well, thank you for coming to the Festival of Ideas.

1822
01:15:05.600 --> 01:15:07.320
<v Robyn Williams>The book, the book of Woe is Unwanted,

1823
01:15:07.340 --> 01:15:07.580
<v Robyn Williams>is upstairs.

1824
01:15:07.820 --> 01:15:09.340
<v Robyn Williams>Would you please thank Gary?

1825
01:15:12.000 --> 01:15:13.040
<v Robyn Williams>Thank you.

1826
01:15:20.220 --> 01:15:24.740
<v Speaker 1>This session of the 2013 Adelaide Festival of Ideas

1827
01:15:24.740 --> 01:15:26.800
<v Speaker 1>was recorded by Radio Adelaide

1828
01:15:26.800 --> 01:15:28.820
<v Speaker 1>through the support of the Bar Smith Library,

1829
01:15:29.180 --> 01:15:30.400
<v Speaker 1>University of Adelaide,

1830
01:15:30.520 --> 01:15:32.400
<v Speaker 1>the University of South Australia Library

1831
01:15:32.400 --> 01:15:34.400
<v Speaker 1>and Flinders University Library.

1832
01:15:37.540 --> 01:15:38.080
<v Speaker 1>Thank you.

